Results 71 to 80 of about 185,612 (294)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Abriu: Estudos de Textualidade do Brasil, Galicia e Portugal, 2019 This article analyses the representation of the Spanish Civil War and fascism in the novels O ano da morte de Ricardo Reis, by José Saramago and El siglo, by Javier Marías.
Gerard Torres Rabassa
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
On the representation of aerosol activation and its influence on model-derived estimates of the aerosol indirect effect [PDF]
Atmospheric Chemistry and Physics, 2018 Interactions between aerosol particles and clouds contribute a great deal of uncertainty to the scientific community's understanding of anthropogenic climate forcing.
D. Rothenberg, A. Avramov, C. Wang
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
American and British Studies Annual, 2018 Tom Robbins’ novel Fierce Invalids Home from Hot Climates (2000) provides a plethora of ways to obtain an insight into his characters’ minds and learn about their feelings and emotions by means of certain techniques of representing speech, thought, and ...
Miloš Blahút
doaj
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Le statut énonciatif des unités dites “transposées” en discours indirect libre
SHS Web of Conferences, 2018 La transposition, concept central de l’approche grammaticale du discours rapporté, a été remise en question par la redéfinition du champ en termes de représentation du discours autre. Le changement de paradigme a imposé de renoncer au schéma selon lequel
Gollut Jean-Daniel, Zufferey Joël
doaj +1 more source
Indirect inference in spatial autoregression
, 2014 Ordinary least squares (OLS) is well-known to produce an inconsistent estimator of the spatial parameter in pure spatial autoregression (SAR). This paper explores the potential of indirect inference to correct the inconsistency of OLS.
Rossi, Francesca +2 more
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Jane Austen, Free Indirect Style, Gender and Interiority in Literary Fiction
, 2018 Austen is known for her development of free indirect style as a narrative form. Free indirect style is a fusion of narrator and character perspectives, a peculiar linguistic manipulation of deictic centres which allows for a semi-experiential ...
Barbara MacMahon, MacMahon, Barbara
core +1 more source