Results 41 to 50 of about 185,612 (294)

On the increased climate sensitivity in the EC-Earth model from CMIP5 to CMIP6 [PDF]

Geoscientific Model Development, 2020
Many modelling groups that contribute to CMIP6 (Coupled Model Intercomparison Project Phase 6) have found a larger equilibrium climate sensitivity (ECS) with their latest model versions compared with the values obtained with the earlier versions used in ...
K. Wyser, T. van Noije, S. Yang, J. von Hardenberg, J. von Hardenberg, D. O'Donnell, R. Döscher   +6 more
doaj   +1 more source

SPEECH, THOUGHT AND WRITING REPRESENTATION MODES IN JANE AUSTENʼS NOVEL SENSE AND SENSIBILITY

Filolog, 2020
Bakhtin’s views (1980:127-130) on the importance of studying speech representation and its interaction with authorial context incited prolific research in various disciplines.
Маја Р. Ковачевић
doaj  

Temporal structure in associative retrieval

eLife, 2015
Electrophysiological data disclose rich dynamics in patterns of neural activity evoked by sensory objects. Retrieving objects from memory reinstates components of this activity. In humans, the temporal structure of this retrieved activity remains largely
Zeb Kurth-Nelson, Gareth Barnes, Dino Sejdinovic, Ray Dolan, Peter Dayan   +4 more
doaj   +1 more source

Exact diagonalization of the D-dimensional spatially confined quantum harmonic oscillator [PDF]

Kragujevac Journal of Science, 2016
In the existing literature various numerical techniques have been developed to quantize the confined harmonic oscillator in higher dimensions. In obtaining the energy eigenvalues, such methods often involve indirect approaches such as searching for the ...
Kunle Adegoke, Olatinwo Adenike, Otobrise Henry, Funmi Akintujoye, Tiamiyu Afees   +4 more
doaj   +1 more source

The origins of perspective taking lie in iconic language use: Unifying theories of signs, conversation, and narrative perspective

Frontiers in Communication, 2023
This paper proposes a theoretical reduction of the existence of perspective taking in discourse to the combination of two basic methods of communication: iconic simulation, and description by means of conventional symbols. This includes an integration of
Arie Verhagen
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source