Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Path analysis and expected response in indirect selection for grain yield in soybean
Crop Breeding and Applied Biotechnology, 2006 This study aimed to determine the best auxiliary trait for indirect selection of soybean grain yield, through path analysis and in avoidance of the adverse effects of multicollinearity and expected response.
Ivana Marino B·rbaro +5 more
doaj
Interrelations between agronomic and technological fiber traits in upland cotton
Acta Scientiarum. Agronomy, 2018 Fiber length stands out among technological traits as one that still needs to be improved in cotton. Thus, the objectives of this work were to quantify the interrelations between agronomic and technological fiber traits and to identify traits that could ...
Paulo Eduardo Teodoro +5 more
doaj +1 more source
Direct and Indirect Selection for Grain Yield and Grain Weight in Late Generations of Bread Wheat under Drought Stress and Normal Irrigation Environments. [PDF]
Plants (Basel), 2022 Mahdy RE +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Appendix E. Model selection summary for analysis of indirect predator effects on cordgrass.
, 2016 Model selection summary for analysis of indirect predator effects on ...
David L. Kimbro (308712)
core +1 more source
Selection for hypocotyl diameter results in genetic gain in common bean plant architecture
Crop Breeding and Applied Biotechnology, 2018 Studies highlight the hypocotyl diameter (HD) as an effective indicator of plant architecture (PA). Here, we estimated the genetic gain based on HD to improve PA.
Rafael Silva Ramos dos Anjos +6 more
doaj
RGB-image method enables indirect selection for leaf spot resistance and yield estimation in a groundnut breeding program in Western Africa. [PDF]
Front Plant Sci, 2022 Sie EK +11 more
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
On the Dynamics of Interstate Migration: Migration Costs and Self-Selection [PDF]
This paper develops a tractable dynamic microeconomic model of migration decisions that is aggregated to describe the behavior of interregional migration.
Bayer, Christian, Juessen, Falko
core