Results 171 to 180 of about 12,102,154 (343)

Heavy resistance exercise training in older men: A responder and inter-individual variability analysis. [PDF]

PLoS One
Soendenbroe C, Andersen JL, Heisterberg MF, Kjaer M, Mackey AL.   +4 more
europepmc   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Inter-individual variability of neurotransmitter receptor and transporter density in the human brain. [PDF]

Brain Struct Funct
Hansen JY, Tuisku J, Johansson J, Chang Z, McGinnity CJ, Beliveau V, Guimond S, Ganz M, Nørgaard M, Galovic M, Bezgin G, Cox SML, Hietala J, Leyton M, Kobayashi E, Rosa-Neto P, Funck T, Palomero-Gallagher N, Knudsen GM, Marsden P, Hammers A, Nummenmaa L, Tuominen L, Misic B.   +23 more
europepmc   +1 more source

Societal and individual determinants of medical care utilization in the United States.

The Milbank Memorial Fund Quarterly Health and Society, 1973
R. Andersen, J. Newman
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Nonparametric Approach to Practical Identifiability of Nonlinear Mixed Effects Models. [PDF]

Bull Math Biol
Cassidy T, Johnston ST, Plank M, Botha I, Flegg JA, Murphy RJ, Hamis S.   +6 more
europepmc   +1 more source

Individual Risk Attitudes: Measurement, Determinants and Behavioral Consequences

, 2009
Thomas Dohmen, A. Falk, David Huffman, U. Sunde, Jürgen Schupp, G. Wagner   +5 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The influence of individual and partner self-esteem on relationship satisfaction: evidence from freshman using actor-partner interdependence model. [PDF]

Front Psychol
Yang Y, Wu Y, Song J.
europepmc   +1 more source

Expression of apelin among the individuals of chronic periodontitis, with and without type ii diabetes mellitus: A study using enzyme-linked immunosorbent assay

, 2020
Santosh Kumar, Tanvi Hirani, Viral Patel, Sagar Hirani, Muhammad Irfan, Deepak Shishoo   +5 more
openalex   +1 more source