Results 81 to 90 of about 5,637,464 (268)
Reaping the fruits of collaboration: learning development research in the LearnHigher CETL network
Journal of Learning Development in Higher Education, 2009 The LearnHigher CETL is now is in its fourth year of developing research-informed resources to support student learning development. Partners at 16 UK Higher Education institutions have amassed a large quantity of data from students and staff on their ...
Kim Shahabudin
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Mental Health ScienceStatistical process control (SPC) was recently introduced as a method for detecting person‐specific warning signals for mental ill‐health. Such warning signals occur when a person's repeatedly assessed emotions exceed a control limit.
Marieke J. Schreuder +5 more
doaj +1 more source
Who Is (Not) Individual: Individualism, Individuality, and Negation
, 2020 Relying on a scene from Monty Python's Life of Brian movie, the article would indicate the characteristically modern dilemmas in the understanding of the category of individual. The speech which Brian delivers to his assembled followers, and the reactions to it, amusingly display typical conceptual problems arising in both, the contemporary crucial and
openaire +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Dark and bright personality dimensions as predictors of criminal behavior and recidivism
Scientific ReportsA growing body of research highlights the continuum between dark and bright personality traits impacting individual prosocial or antisocial tendencies.
Liliana Hurezan +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source