Results 91 to 100 of about 3,676,382 (322)

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Metric-Free Individual Fairness with Cooperative Contextual Bandits [PDF]

arXiv, 2020
Data mining algorithms are increasingly used in automated decision making across all walks of daily life. Unfortunately, as reported in several studies these algorithms inject bias from data and environment leading to inequitable and unfair solutions. To mitigate bias in machine learning, different formalizations of fairness have been proposed that can
arxiv  

Inherent Individual Differences in Utility [PDF]

Frontiers in Psychology, 2011
Opinion Article published: 15 November 2011 doi: 10.3389/fpsyg.2011.00297 Inherent individual differences in utility R. Duncan Luce* Institute for Mathematical Behavioral Sciences, University of California, Irvine, CA, USA *Correspondence: rdluce@uci.edu 1 Who knows a utility representation Repeatedly it is alleged that this or that theory concerns a ...
openaire   +5 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Prosocial behavior in convicted offenders: A scoping review

Studia Universitatis Babeş-Bolyai. Psychologia-Paedagogia
Despite considerable interest and relevance to the broader community, prosocial behavior in prisons remains an understudied topic. The purpose of the present study was to summarize existing research on prosocial behavior among incarcerated offenders.
Liliana HUREZAN, Sara Maria JUGANARU, Ioana-Anastasia GORAN, Elena Emanuela VELICEA, Laura VISU-PETRA   +4 more
doaj   +1 more source

The impact of nodes of information dissemination on epidemic spreading in dynamic multiplex networks [PDF]

Epidemic spreading processes on dynamic multiplex networks provide a more accurate description of natural spreading processes than those on single layered networks. To describe the influence of different individuals in the awareness layer on epidemic spreading, we propose a two-layer network-based epidemic spreading model, including some individuals ...
arxiv   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Algorithms for an Efficient Tensor Biclustering [PDF]

arXiv, 2019
Consider a data set collected by (individuals-features) pairs in different times. It can be represented as a tensor of three dimensions (Individuals, features and times). The tensor biclustering problem computes a subset of individuals and a subset of features whose signal trajectories over time lie in a low-dimensional subspace, modeling similarity ...
arxiv  

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source