Results 91 to 100 of about 12,300,569 (293)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Environmental quality shapes the fitness payoffs of multiple paternity

BMC Ecology and Evolution
Background Polyandry is widespread in nature and, in polygynandrous species, can lead to multiple paternity when a litter is sired by more than one male. Such multiply-sired litters have been suggested to produce benefits in low-quality environments that
Fragkiskos Darmis, Anja Guenther
doaj   +1 more source

Further Evidence of Independence Between the Motive to Achieve Success and the Motive to Avoid Failure: A Confirmatory Factor Analysis

Psychologica Belgica, 2011
The Motive to Achieve Success (MAS) and the Motive to Avoid Failure (MAF) are the most widely measured factors of achievement motivation. The relationships between MAS and MAF are controversial.
Rémi L Capa, Michel Audiffren, Nathalie André, Michel Hansenne   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Coping in healthcare personnel: certain coping strategies as predictors of anxiety and depression

BJPsych Open
Background Healthcare personnel exhibit higher levels of anxiety and depression, with differences in the use of coping strategies to manage stressful situations.
Paula García-Barja, Beatriz Talavera-Velasco, Daniel Vázquez-Estévez, Lourdes Luceño-Moreno   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Individual Differences in Need for Cognition and Decision-Making Competence among Leaders [PDF]

, 2011
When making decisions, people sometimes deviate from normative standards. While such deviations may appear to be alarmingly common, examining individual differences may reveal a more nuanced picture.
Lerner, Jennifer, Jennifer S Lerner, Carnevale, Jessica J., Jennifer S. Lerner, Yoel Inbar, Lerner, Jennifer S, Jessica J. Carnevale, Inbar, Yoel, Jessica J Carnevale, Carnavale, Jessica J   +9 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Individual differences in attachment and dispositional mindfulness: The mediating role of emotion regulation

, 2013
Recent interest in the relationship between individual differences in attachment and dispositional mindfulness has led to empirical investigations into this association.
Pepping, Chris, O'Donovan, Analise, Pepping, Christopher A, Davis, Penelope J, Davis, Penelope   +4 more
core   +1 more source