Results 91 to 100 of about 32,743,025 (287)

Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials: Guidance on Their Use [PDF]

, 2015
Jayne Tierney and colleagues offer guidance on how to spot a well-designed and well-conducted individual participant data meta ...
Rovers, M., Clarke, M., Tierney, JF, Riley, R., Rovers, M, Stewart, L., Vale, C., Riley, R.; id_orcid, Riley, R, Tierney, J.F., Vale, C, Smith, CT, Stewart, L, Smith, C.T., Clarke, M, Rovers, M.M., Mike Clarke, Stewart Lesley, Maroeska Rovers, Tierney, Jayne F, Vale Claire, Vale, Claire, Stewart, Lesley, Clarke, Mike; id_orcid, Clarke Mike, Jayne F Tierney, Smith Catrin Tudur, Clarke, Mike, Claire Vale, Rovers, Maroeska, Richard Riley, Rovers Maroeska, Riley Richard, Riley, Richard, Smith, Catrin Tudur, Catrin Tudur Smith, Tierney Jayne F., Lesley Stewart   +37 more
core   +3 more sources

Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak, Katarzyna Bilska, Tomasz Koziński, Jadwiga Węcławek‐Tompol, Dorota Sega‐Pondel, Radosław Chaber, Wanda Badowska, Katarzyna Rosłan, Hanna Koseła‐Paterczyk, Anna Raciborska   +9 more
wiley   +1 more source

DNA Data Marketplace: An Analysis of the Ethical Concerns Regarding the Participation of the Individuals [PDF]

Frontiers in Genetics, 2019
Les données génomiques personnelles et les données de santé connexes sont des ressources précieuses à la fois pour la recherche financée par des fonds publics et pour les entités à but lucratif dans le développement de nouveaux médicaments, thérapies et tests de diagnostic.
Eman Ahmed, Eman Ahmed, Mahsa Shabani, Mahsa Shabani   +3 more
openaire   +5 more sources

Individual participant data meta-analysis of prognostic factor studies: state of the art?

BMC Medical Research Methodology, 2012
Background Prognostic factors are associated with the risk of a subsequent outcome in people with a given disease or health condition. Meta-analysis using individual participant data (IPD), where the raw data are synthesised from multiple studies, has ...
Abo-Zaid Ghada, Sauerbrei Willi, Riley Richard D   +2 more
doaj   +1 more source

Feeding, Fear, and Acceptance: Caregivers’ Experiences of Nutritional Support During Childhood Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques, Mariana dos Santos Murra, Welinton Hirai, Ana Laura Balduino do Nascimento, Karla Emilia de Sá Rodrigues, Wilson Elias de Oliveira Junior   +5 more
wiley   +1 more source

Adverse fetal and perinatal outcomes associated with Zika virus infection during pregnancy ::an individual participant data meta-analysis

Background: Zika virus (ZIKV) infection during pregnancy is associated with an increased risk of congenital malformations. The prevalence of short and long-term consequences, however, remains uncertain due to heterogeneity across studies.
The Zika Virus Individual Participant Data Consortium, Pomar, Léo   +1 more
core   +1 more source

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source

Representation of Sickle Cell Disease Patients in Pediatric and Adult Care: What We Discovered Using Informatics for Integrating Biology and the Bedside (i2b2) Data

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Transitioning from pediatric to adult care is a high‐risk period for individuals with sickle cell disease (SCD). An initial observation at one academic medical center suggested a sex‐based disparity in clinic populations, prompting a national investigation.
Laurie J. Duckworth, Kholod Alhassan, Ada De La Osa, John Stephen, Yue Yao, Diana J. Wilkie   +5 more
wiley   +1 more source

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source

Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis

Health Technology Assessment, 2019
Background: Randomised controlled trials (RCTs) exploring the potential of vitamin D to prevent acute respiratory infections have yielded mixed results.
Adrian R Martineau, David A Jolliffe, Lauren Greenberg, John F Aloia, Peter Bergman, Gal Dubnov-Raz, Susanna Esposito, Davaasambuu Ganmaa, Adit A Ginde, Emma C Goodall, Cameron C Grant, Wim Janssens, Megan E Jensen, Conor P Kerley, Ilkka Laaksi, Semira Manaseki-Holland, David Mauger, David R Murdoch, Rachel Neale, Judy R Rees, Steve Simpson, Iwona Stelmach, Geeta Trilok Kumar, Mitsuyoshi Urashima, Carlos A Camargo, Christopher J Griffiths, Richard L Hooper   +26 more
doaj   +1 more source