Results 111 to 120 of about 32,743,025 (287)

The Impact of Tenapanor on Body Composition and Blood Pressure in Peritoneal Dialysis Patients: A Pilot Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Instruction Tenapanor potentially affects fluid volume and blood pressure. This study explored its effects on these parameters in patients undergoing peritoneal dialysis (PD). Methods We conducted a single‐arm, prospective observational study that enrolled 10 patients on PD with hyperphosphatemia who were newly initiated on tenapanor.
Shun Yoshida, Kengo Asahina, Keiichi Osano, Natsumi Saegusa, Kohei Yamamura, Kie Ohkoshi, Miho Shikata, Toshihisa Ishii, Makiko Konishi, Kazuya Takahashi, Kohei Uchimura, Ayumu Nakashima   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The state of individual participant data sharing for the highest-revenue medicines

Clinical Trials
Background Amid growing emphasis from pharmaceutical companies, advocacy groups, and regulatory bodies for sharing of individual participant data, recent audits reveal limited sharing, particularly for high-revenue medicines.
Natansh D Modi, Lee X Li, Jessica M Logan, Michael D Wiese, Ahmad Y Abuhelwa, Ross A McKinnon, Andrew Rowland, Michael J Sorich, Ashley M Hopkins   +8 more
openaire   +2 more sources

Methodological Guidance for Individual Participant Data Meta-Analyses: A Systematic Review [PDF]

Journal of Clinical Epidemiology
To systematically identify and synthesize methodological guidance for conducting individual participant data meta-analyses (IPD-MAs) of randomized trials and observational studies, to inform the development of a critical appraisal tool for reports of IPD-MAs.We searched nine major electronic databases and gray literature sources through June 2025 using
Edith Ginika Otalike, Mike Clarke, Farjana Akhter, Areti Angeliki Veroniki, Ngianga-Bakwin Kandala, Joel J. Gagnier   +5 more
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The Value of Further Research: The Added Value of Individual-Participant Level Data

Applied Health Economics and Health Policy, 2019
Judgements based on average cost-effectiveness estimates may disguise significant heterogeneity in net health outcomes. Decisions about coverage of new interventions are often more efficient when they consider between-patient heterogeneity, which is usually operationalized as different selections for different subgroups.
Saramago, Pedro, Espinoza, Manuel A, Sutton, Alex J, Manca, Andrea, Claxton, Karl   +4 more
openaire   +5 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Therapeutic Vaccines for Follicular Lymphoma: A Systematic Review

Pharmaceuticals
(1) Background: We aimed to estimate the pooled effectiveness and safety of vaccination in follicular lymphoma (FL) and discuss implications for immunotherapy development.
Andrei Suponin, Pavel Zhelnov, Artem Potanin, Andrey Chekalov, Aleksandr Lomazov, Kseniia Vladimirova, Kirill Lepik, Albert Muslimov   +7 more
doaj   +1 more source

Optimism in adults born preterm: Systematic review and individual-participant-data meta-analysis

PLoS ONE, 2021
Aim Preterm birth(
Rachel K. Robinson, Kati Heinonen, Polina Girchenko, Marius Lahti-Pulkkinen, Eero Kajantie, Petteri Hovi, Aulikki Lano, Sture Andersson, Johan G. Eriksson, Dieter Wolke, Sakari Lemola, Katri Räikkönen   +11 more
doaj  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source