Results 201 to 210 of about 32,743,025 (287)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Modifiers of effectiveness and deterioration, and prognostic factors of adherence in internet-based interventions for treatment of perinatal depression: A systematic review and individual participant data meta-analysis. [PDF]

Internet Interv
Ciharova M, Cuijpers P, Harrer M, Hirshler Y, Panagiotopoulou OM, Tong L, Miguel C, Frankova I, Gemmill AW, Buntrock C, van Ballegooijen W, Fonseca A, Branquinho M, Forsell E, Pugh NE, Hadjistavropoulos HD, Sun Y, Franco P, Barquero-Jiménez C, Gómez-Gómez I, Motrico E, Fonseca Zuccolo P, Fatori D, Milgrom J, Karyotaki E.   +24 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Convergent structural brain alterations in chronic pain: a multi-metric individual participant data meta-analysis. [PDF]

Brain Commun
Loke RWJ, Ortiz O, Gustin SM, Hubli M, Linnman C, Livny A, Quidé Y, Scheuren PS, Kramer JLK.   +8 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Effect Modification Analyses in Individual Participant Data Meta-Analyses: A Systematic Review.

JAMA Netw Open
Gao Y, Li Z, Liu M, Zhao Y, Asadollahifar A, Yang K, Shi S, Daneshmand M, Xu J, Yao L, Yang F, Xue F, Tian J, Zhang J, Guyatt G.   +14 more
europepmc   +1 more source

The efficacy of antidepressant medication versus interpersonal psychotherapy for depression in middle-aged women: a systematic review and individual participant data meta-analysis. [PDF]

Arch Womens Ment Health
van Haaren SNE, Cohen ZD, Breunese J, Wienicke FJ, Markowitz JC, Weitz ES, Hollon SD, Browne DT, Rucci P, Corda C, Menchetti M, Weissman MM, Bagby RM, Quilty LC, Blom MBJ, Altamura M, Zobel I, Schramm E, Gois C, Twisk JWR, Cuijpers P, Driessen E.   +21 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

HBsAg decline and clearance with peg-IFN therapy added to nucleos(t)ide analogues: an individual participant data meta-analysis of prospective trials (PROSPER). [PDF]

Gut
Dongelmans EJ, Patmore LA, Lim SG, Bourliere M, Jiang S, Ganne-Carrie N, Brouwer WP, Feld JJ, Huang Y, Carrion JA, Broquetas T, Hu Q, Fung S, Carrat F, Zoulim F, Hansen BE, Xie Q, Janssen HLA, Sonneveld MJ.   +18 more
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source