Results 221 to 230 of about 32,743,025 (287)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Correction to: Sudden cardiac death after myocardial infarction: individual participant data from pooled cohorts. [PDF]

Eur Heart J
europepmc   +1 more source

Intrauterine human chorionic gonadotropin administration before embryo transfer (IHABT): an individual participant data meta-analysis of randomized controlled trials. [PDF]

Hum Reprod Update
Zou H, Abdallah KS, Wirleitner B, Hong KH, Thanaboonyawat I, Laokirkkiat P, Hafezi M, Kokeguchi S, Makhlouf A, Libesman S, Nguyen D, Williams JG, Showell M, Gadalla M, Mol BWJ, Li W, Wang R.   +16 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Distant Cutaneous Metastasis of Chordoma: A Systematic Review and Individual-Participant-Data Meta-Analysis of 52 Cases, with an Illustrative Poorly Differentiated Index Case. [PDF]

Cells
Neamțu AA, Chioibaș R, Goldenberg A, Maghiar L, Barna R, Iftode A, Grecu T, Taban S, Andea A.   +8 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Multiple Adverse Outcomes Associated with Risperidone in People with Dementia: An Individual Participant Data Meta-Analysis. [PDF]

CNS Drugs
Le HT, Lau ECY, Lu CY, Hilmer SN, Jeon YH, Low LF, Nguyen TA, Tan ECK.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Prognostic value of cervical length for spontaneous preterm birth in asymptomatic women with singleton pregnancy: An individual participant data meta-analysis. [PDF]

PLoS Med
Hughes K, Nguyen D, Aberoumand M, Ford H, Clarke E, Banos Lopez N, Dziadosz M, Fischer R, Souza RT, Cecatti JG, Orzechowski K, Olson-Chen C, Peixoto AB, Phupong V, Rosenbloom J, Son M, Souka A, Du L, Esplin MS, Granese R, Gupta S, Kazemier B, Kindinger L, Kuusela P, Van der Ven J, Weitzner O, Minis E, Llobet AF, Frey H, Bagga R, Mishra S, Patberg E, Bennett P, Hall M, Shennan A, Brennecke S, Thangaratinam S, Seidler AL, Mol BW, Wang R.   +39 more
europepmc   +1 more source