Results 51 to 60 of about 5,147,796 (325)
Resilience, adaptive capacity, and the lock-in trap of the Western Australian agricultural region [PDF]
, 2004 Using the Western Australian (WA) agricultural region as an example of a large-scale social-ecological system (SES), this paper applies a framework based on resilience theory to examine the region's resilience and capacity for change and renewal. Despite
Allison, H.E. +3 more
core +1 more source
Offre d’expérience agrotouristique, COVID-19 et capacité de résilience
Téoros, 2020 While the 2020 agritourism season was being prepared, the actors of the cider industry in Quebec were abruptly discovering the business risks associated with agritourism activities. The health crisis provoked by the COVID-19 pandemic in March 2020 breeds
L. Martin Cloutier, Laurent Renard
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Perception, experience and resilience to risks: a global analysis
Scientific Reports, 2023 Individual resilience is crucial amid rising global threats, yet risk perceptions and resilience worldwide remain inadequately elucidated. This research pioneers a global-scale analysis of individual risk perspectives and perceived resilience capacities.
Minh Kieu, Gayani Senanayake
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
An Investigation of the Communal and Individual Resilience of Immigrant Women in New Zealand [PDF]
, 2014 Some immigrant women face triple discrimination due to their, gender, ethnicity and immigrant status. The voices of immigrant women are absent from literature on immigration, furthermore the experience of immigrant women are omitted as prominent ...
Okuyama, Lucinda,, Okuyama, Lucinda
core
Promoting Intern Resilience: Individual Chief Wellness Check-ins
MedEdPORTAL, 2019 Introduction Promoting resilience is key during intern year as residents transition to becoming clinical providers. Residents consistently demonstrate a decline in empathy and an increase in burnout throughout training.
Jason Fischer +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source