Results 61 to 70 of about 5,147,796 (325)

Short research report : exploring resilience development in a Taiwanese preschooler’s narrative : an emerging theoretical model [PDF]

, 2016
Short Research Report:Exploring resilience development in a Taiwanese preschooler’s narrative: An emerging theoretical model.peer ...
Kuan-Ling Olivia Lin, Lin, Kuan-Ling Olivia, Lin, Kuan-Ling   +2 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Developing transformative schools : a resilience-focused paradigm for education [PDF]

, 2014
For the better part of the past century, the field of education has witnessed repeated calls and initiatives for change, reform and improvement of our schools. Yet today, the problems of improving academic achievement and social adjustment among youth
Nicoll, William G., William G. Nicoll
core   +1 more source

Efficacy of a self-help manual in increasing resilience in carers of adults with depression in Thailand [PDF]

, 2016
Caring for a person with a mental illness can have adverse effects on caregivers; however, little is known about how best to help such caregivers. The aim of the present study was to examine the efficacy of a cognitive behaviour therapy-guided self-help ...
McCann, Terence V., McCann, Terence, Terence V. McCann, Songprakun, Wallapa, Stephenson, John, John Stephenson, Songprakun, W, Stephenson, J, Wallapa Songprakun   +8 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Quantification of the Ecological Resilience of Drylands Using Digital Remote Sensing [PDF]

, 2008
Drylands cover 41% of the terrestrial surface and support > 36% of the world's population. However, the magnitude of dryland degradation is unknown at regional and global spatial scales and at 15-30-yr temporal scales.
R. D. Ramsey, Robert A. Washington-Allen, Neil E. West, Ramsey, R. D., Brien E. Norton, Washington-Allen, Robert A., West, Neil E., Norton, Brien E.   +7 more
core   +1 more source

An examination of the effects of family, school, and community resilience on high school students’ resilience in China

Frontiers in Psychology
IntroductionResilience plays a pivotal role in shaping the academic accomplishments, psychological well-being, and future prospects of high school students.
Chunlin Qi, Nanchang Yang
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source