Results 171 to 180 of about 308,507 (245)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

National cultural characteristics as defined by Hofstede's dimensions and their associations with population health. [PDF]

BMC Public Health
Zidkova R, Furstova J, Malinakova K, van Dijk JP, Tavel P, Gulis G.   +5 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Cultural influences on fidelity components in recovery colleges: a study across 28 countries and territories. [PDF]

Gen Psychiatr
Kotera Y, Ronaldson A, Takhi S, Felix S, Namasaba M, Lawrence S, Kellermann V, Kapka A, Hayes D, Dunnett D, Jebara T, Murakami M, Bakolis I, Repper J, Meddings S, Stergiopoulos V, Brophy L, De Ruysscher C, Eplov L, Toernes C, Narusson D, Puschner B, Hiltensperger R, Miyamoto Y, Castelein S, Klevan TG, Morland-Jones H, Moore E, Tse S, Ryan M, Zuaboni G, Hanlon C, Asher L, Vanderplasschen W, Ochoa S, Tolonen J, Charles A, Andrade M, Elton D, Bates P, Cooper J, Grant J, Henderson C, Slade M.   +43 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Individualism and Collectivism as Moderators of Relations between Adverse Childhood Experiences and Adolescent Aggressive Behavior. [PDF]

Res Child Adolesc Psychopathol
Dang HM, Le T, Chau C, Nguyen PT, Weiss B.   +4 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Helping Across Boundaries: Collectivism and Hierarchy in the Ultra-Orthodox Context. [PDF]

Behav Sci (Basel)
Goldfinger C, Shahar-Rosenblum S, Trachtengot I, Malovicki-Yaffe N.   +3 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Emerging, challenges and modernization path of gene privacy in China: from personal privacy to group privacy. [PDF]

Philos Ethics Humanit Med
Chen J, Li W.
europepmc   +1 more source