Results 61 to 70 of about 169,269 (340)

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Synthesis of 2-Methyl-3-indolylacetic Derivatives as Anti-Inflammatory Agents That Inhibit Preferentially Cyclooxygenase 1 without Gastric Damage [PDF]

, 2006
Novel substituted 2-methyl-3-indolylacetic derivatives were synthesized and evaluated for their activity in vitro and in vivo on COX-1 and COX-2. Active compounds were screened to determine their gastrointestinal tolerability in vivo in the rat.
C. Renner, CALIENDO, GIUSEPPE, CIRINO, GIUSEPPE, FIORINO, FERDINANDO, PERISSUTTI, ELISA, ROSSI, ANTONIETTA, ROVIEZZO, FIORENTINA, SANTAGADA, VINCENZO, SAUTEBIN, LIDIA, SEVERINO, BEATRICE   +9 more
core   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
Single‐cell transcriptomic and functional analyses identify SEMA3C as a key regulator of tumor progression and tumor microenvironment remodeling in penile squamous cell carcinoma. SEMA3C promotes epithelial–mesenchymal transition, tumor growth, and invasion while shaping an immunosuppressive microenvironment, highlighting its potential as a prognostic ...
Xiheng Hu, Wensheng Shi, Liang Dong, Lingjuan Huang, Xiyuan Zhang, Yiting Feng, Jie Sun, Lanlan Liu, Teng Liu, Jun Fu, Bowen Zhong, Qihao Leng, Xiaohua Wu, Minfeng Chen, Lingfang Li, Yuan Li, Xin Jin, Long Wang, Jian Cao, Xin Li, Mingzhu Yin, Xiang Chen   +21 more
wiley   +1 more source

Differences in the Abundance of Auxin Homeostasis Proteins Suggest Their Central Roles for In Vitro Tissue Differentiation in Coffea arabica

Plants, 2021
Coffea arabica is one of the most important crops worldwide. In vitro culture is an alternative for achieving Coffea regeneration, propagation, conservation, genetic improvement, and genome editing.
Ana O. Quintana-Escobar, Hugo A. Méndez-Hernández, Rosa M. Galaz-Ávalos, José M. Elizalde-Contreras, Francisco A. Reyes-Soria, Victor Aguilar-Hernández, Eliel Ruíz-May, Víctor M. Loyola-Vargas   +7 more
doaj   +1 more source

The Effect of Indole-3-Acetic Acid (IAA) on the Activity Levels of Dehydrogenases in the Silkgland of Silkworm, Bombyx Mori L [PDF]

, 2016
The effect of indole-3-acetic acid (IAA) on the glucose-6-phosphate dehydrogenase (G-6-PDH),lactate dehydrogenase (LDH), glutamate dehydrogenase (GDH), iso-citrate dehydrogenase (ICDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH) were ...
Bharathi, D. (D), Lakshmikantham, V. (V)
core  

An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm

Advanced Science, EarlyView.
An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.
Kui Han, Meimei Liao, Jingpeng Zhang, Ruoyu Zhong, Long Mei, Dapeng Ju, Eric Erquan Zhang, Yanyi Huang   +7 more
wiley   +1 more source

Studies of the physiology, pharmacology, and biochemistry of the auxins [PDF]

, 1952
Several excellent reviews of auxin matters have appeared during the past few years dealing broadly with the subject as a whole, such as the Wisconsin Symposium on Plant Growth Substances whleh is referred to repeatedly below, as well as reviews of more ...
Bandurski­, Robert S., Bonner, James
core   +1 more source

Comprehensive Genome Analysis on the Novel Species Sphingomonas panacis DCY99(T) Reveals Insights into Iron Tolerance of Ginseng [PDF]

, 2020
Plant growth-promoting rhizobacteria play vital roles not only in plant growth, but also in reducing biotic/abiotic stress. Sphingomonas panacis DCY99(T) is isolated from soil and root of Panax ginseng with rusty root disease, characterized by raised ...
Balusamy, Sri Renukadevi, Huo, Yue, Kim, Donghyuk, Kim, Yeon-Ju, Le, Hoa Thi, Nong, Linh Khanh, Park, Joon Young, Yang, Deok Chun   +7 more
core   +1 more source

Gas chromatographic determination of urinary indole-3-acetic acid.

Chemical and Pharmaceutical Bulletin, 1977
Gas chromatographic analysis of urinary indole-3-acetic acid as the trifluoroacetyl derivative of its methyl ester was carried out. A 10 ml portion of urine sample, acidified and saturated with sodium chloride, was extracted with benzene. After methylation with diazomethane in ether, indole-3-acetic acid was converted to the trifluoroacetyl derivative.
H, Naruse, N, Kato, E, Nasu, S, Kawai, K, Hashimoto, Y, Masada, T, Ohno   +6 more
openaire   +3 more sources