Results 271 to 280 of about 172,313 (331)

Biotinylated Indoles as Probes for Indole-Binding Proteins

Bioconjugate Chemistry, 2001
Biotinylated indoles were prepared for application as bifunctional probes for the detection of indole-binding proteins which participate in the life processes of humans, animals, plants, and bacteria. The indole nucleus was functionalized, at ring positions 3, 5, or 6, by attachment of a 2-aminoethyl group, which was then coupled to the carboxyl moiety
Volker Magnus, Jennifer Normanly, Mariusz Kowalczyk, Eduard Dolusic, Göran Sandberg   +4 more
openaire   +5 more sources

Organocatalytic Asymmetric Annulation of ortho-Alkynylanilines: Synthesis of Axially Chiral Naphthyl-C2-Indoles.

Angewandte Chemie, 2019
A chiral Brønsted base-catalyzed asymmetric annulation of ortho-alkynylanilines has been developed to access axially chiral naphthyl-C2-indoles through vinylidene ortho-quinone methides (VQMs) intermediates.
Lei Peng, Kai Li, Chuandong Xie, Shan Li, Dashuang Xu, Wenling Qin, Hailong Yan   +6 more
semanticscholar   +1 more source

Substrate specificity of caeruloplasmin indoles and indole isosteres

Biochemical Pharmacology, 1973
Abstract Several indoles and indole isosteres have been examined as potential substrates for the oxidative enzyme caeruloplasmin. Amongst the indoles the presence of a hydroxy group on the aromatic ring of the indole nucleus is a necessary requirement for substrate activity; this hydroxy group may be at position 4, 5 or 6 of the indole nucleus.
B.C. Barrass, D.B. Coult, R. M. Pinder, Malcolm Skeels   +3 more
openaire   +3 more sources

Synthesis of indoles via domino reaction of 2-fluorotoluenes and nitriles.

Angewandte Chemie, 2019
Indoles are essential heterocycles in medicinal chemistry and, therefore, novel and efficient approaches to their synthesis are in high demand. Among indoles, 2-aryl indoles have been described as privileged scaffolds.
Jianyou Mao, Zhiting Wang, Xinyu Xu, Guoqing Liu, Runsheng Jiang, Haixing Guan, Zhipeng Zheng, P. Walsh   +7 more
semanticscholar   +1 more source

‘Indolent’ plasmacytoma

Australasian Radiology, 2001
SUMMARYA patient presented with lethargy, nausea and diarrhoea and had a 10‐year history of neurological symptoms in his legs. He was found to have renal failure. Investigations demonstrated a longstanding plasmacytoma of the sacrum and progression to myeloma. Such an indolent course for plasmacytoma is rare.
D, Stewart, P, Price
openaire   +2 more sources

Bartoli Indole Synthesis

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
DALPOZZO, Renato, Bartoli G.
openaire   +3 more sources

Cyclohepta[b]indoles: A Privileged Structure Motif in Natural Products and Drug Design.

Accounts of Chemical Research, 2016
Seven-membered rings fused with an indole are termed cyclohepta[b]indoles. Compounds exhibiting this structure motif display a broad spectrum of biological activities, ranging from inhibition of adipocyte fatty-acid-binding protein (A-FABP ...
Erik Stempel, T. Gaich
semanticscholar   +1 more source

Palladium-Catalyzed C-H Arylation of Indoles at the C7 Position.

Journal of the American Chemical Society, 2016
In the past decade, direct C-H arylation of indoles has been developed with high selectivity at the C2 and C3 positions via transition-metal-catalyzed cross-coupling reactions. Here we show that C-H activation can be directed to the C7 position with high
Youqing Yang, Xiaodong Qiu, Yue Zhao, Yucheng Mu, Zhuangzhi Shi   +4 more
semanticscholar   +1 more source

Indoles - Gut Bacteria Metabolites of Tryptophan with Pharmacotherapeutic Potential.

Current drug metabolism, 2018
BACKGROUND Increasing evidence proves the pivotal role of gut microbiota in mammals' homeostasis. Gut bacterial metabolites may exert local effects on the intestines, and may enter the circulation, affecting the functions of virtually all organs.
P. Konopelski, M. Ufnal
semanticscholar   +1 more source

ChemInform Abstract: Vibronic Analysis of Indole and 1H‐Indole‐d6

ChemInform, 1993
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thomas M. Dunn, David M. Lubman, Toni L. O. Barstis, Louis I. Grace   +3 more
openaire   +3 more sources