Results 131 to 140 of about 6,601,283 (299)

Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells [PDF]

, 2013
Mohammad Abul Kalam Azad, B.A. Finnin, Anima Poudyal, Kathryn E. Davis, Jinhua Li, Prue Hill, Roger L. Nation, Tony Velkov, Jian Li   +8 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Pheophorbide a, an active compound isolated fromScutellaria barbata, possesses photodynamic activities by inducing apoptosis in human hepatocellular carcinoma [PDF]

, 2006
Patrick Ming‐Kuen Tang, Judy Yuet‐Wa Chan, Shannon Wing‐Ngor Au, Siu‐Kai Kong, Stephen Kwok‐Wing Tsui, Mary Miu Yee Waye, Thomas C. W. Mak, Wing‐Ping Fong, Kwok‐Pui Fung   +8 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1α-Mediated Glycolytic Adaptation

, 2009
Maria Ripoli, Annamaria D’Aprile, Giovanni Quarato, Magdalena Filipowicz Sinnreich, Jérôme Gouttenoire, Rosella Scrima, Olga Cela, Domenico Boffoli, Markus H. Heim, Darius Moradpour, Nazzareno Capitanio, Cláudia Piccoli   +11 more
openalex   +2 more sources

First-in-man application of a novel therapeutic cancer vaccine formulation with the capacity to induce multi-functional T cell responses in ovarian, breast and prostate cancer patients [PDF]

, 2012
Neil L. Berinstein, Mohan Karkada, Michael A. Morse, John Nemunaitis, Gurkamal Chatta, Howard L. Kaufman, Kunle Odunsi, Rita Nigam, Leeladhar Sammatur, Lisa D. MacDonald, Genevieve Weir, Marianne M. Stanford, Marc Mansour   +12 more
openalex   +1 more source

The Arabidopsis Hypoxia Inducible AtR8 Long Non-Coding RNA also Contributes to Plant Defense and Root Elongation Coordinating with WRKY Genes under Low Levels of Salicylic Acid [PDF]

, 2020
Shuang Li, Saraswati Nayar, HuiYuan Jia, Sanjay Kapoor, Juan Wu, Yasushi Yukawa   +5 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling [PDF]

, 2019
Arunas Kvainickas, Heike Nägele, Wenjing Qi, Ladislav Dokládal, Ana Jimenez‐Orgaz, Luca Stehl, Dipak Gangurde, Qian Zhao, Zehan Hu, Jörn Dengjel, Claudio De Virgilio, Ralf Baumeister, Florian Steinberg   +12 more
openalex   +1 more source