Results 161 to 170 of about 6,601,283 (299)
Biochanin A Regulates Key Steps of Inflammation Resolution in a Model of Antigen-Induced Arthritis via GPR30/PKA-Dependent Mechanism
, 2021 Franciel Batista Félix, Juliana P. Vago, Débora de Oliveira Fernandes, Débora Gonzaga Martins, Isabella Zaidan, William Antônio Gonçalves, Walyson Coelho Costa, Jéssica Maria Dantas Araújo, Celso Martins Queiroz‐Junior, Gabriel Henrique Campolina-Silva, Frederico Marianetti Soriani, Lirlândia P. Sousa, Renata Grespan, Mauro Martins Teixeira, Vanessa Pinho +14 moreopenalex +1 more sourceReduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourcePlasma-activated solutions reverse chronic deltamethrin exposure induced intestinal injury via rebalancing redox homeostasis and counteracting cellular senescence. [PDF]
Sci RepDeng X, Sun T, Wang S, Ren K, Min T, Ma Y, Peng Y, Wang X, Zhang B, Nan Y, Tong S, Liu Y, Wang W, Zhang Y, Yang Y, Li K, Dang C, Zhang H, Zhu K. +18 moreeuropepmc +1 more sourceLiquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen +2 morewiley +1 more sourceDifferential roles of Rad18 in repressing carcinogen- and oncogene-driven mutagenesis <i>in vivo</i>. [PDF]
NAR CancerAnand JR, Brown BW, Lou J, Gu Q, Yang Y, Droby G, Wu D, Jena A, Xie J, Fedoriw Y, Weissman B, Williams S, Vaziri C. +12 moreeuropepmc +1 more sourceDexmedetomidine Inhibits Gasdermin D-Induced Pyroptosis via the PI3K/AKT/GSK3β Pathway to Attenuate Neuroinflammation in Early Brain Injury After Subarachnoid Hemorrhage in Rats
, 2022 Boyang Wei, Wenchao Liu, Lei Jin, Shenquan Guo, Haiyan Fan, Fa Jin, Chengcong Wei, Dazhao Fang, Xin Zhang, Shixing Su, Chuanzhi Duan, Xifeng Li +11 moreopenalex +1 more sourceIntein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar +9 morewiley +1 more sourceLidocaine induces apoptosis in head and neck squamous cell carcinoma through activation of bitter taste receptor T2R14
, 2023 Zoey A. Miller, Arielle Mueller, Tae‐Beom Kim, Jennifer F. Jolivert, Ray Z., Sahil Muthuswami, April Park, Derek B. McMahon, Kevin T. Nead, Ryan M. Carey, Robert J. Lee +10 moreopenalex +1 more source