Results 291 to 300 of about 19,750,469 (329)

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Immune checkpoint inhibitor-induced thyroiditis and its potential mechanisms. [PDF]

Front Endocrinol (Lausanne)
Mao X, Mao C, Liu J, Wang X, Mao Y.
europepmc   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Nimbolide Targeting SIRT1 Protects Against Acetaminophen-Induced Acute Liver Injury by Regulating Oxidative Stress and Endoplasmic Reticulum Stress. [PDF]

Pharmacol Res Perspect
Ba J, Lin Y, Zhang J, Wang Y, Wu B.
europepmc   +1 more source

Real-world data of docetaxel-induced liver injury among hospitalized patients in Wuhan, China: A retrospective analysis. [PDF]

Medicine (Baltimore)
Zhan H, Deng Y, Huang C, Yang JX, Yang J.   +4 more
europepmc   +1 more source

Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2. [PDF]

Mol Med
Luo S, Yang M, Jiang N, Li C, Liu Y, Sun L.   +5 more
europepmc   +1 more source

FLASH-induced DNA damage reduction measured in vitro correlates with effective oxygen depletion determined in silico: further support for oxygen depletion contributing to FLASH's reduced damage burden in vitro. [PDF]

Br J Radiol
Rothwell B, Cooper CR, Jones DJL, Merchant MJ, Kirkby NF, Kirkby KJ, Petersson K, Schuemann J, Jones GDD.   +8 more
europepmc   +1 more source

The DJ-1-Binding Compound Exerts a Protective Effect in Both In Vitro and In Vivo Models of Sepsis-Induced Acute Kidney Injury. [PDF]

Antioxidants (Basel)
Zrufkó R, Pajtók C, Szebeni B, Veres-Székely A, Bernáth M, Szász C, Bokrossy P, Szabó AJ, Vannay Á, Pap D.   +9 more
europepmc   +1 more source

The role and mechanism of PGC-1α in oxLDL-induced ferroptosis of vascular endothelial cells. [PDF]

Atheroscler Plus
Li J, He P, Zhang Y, Zhao R, Shen C, Li C, Liu W, Liu Z, Long X, Wang Y, Shi B.   +10 more
europepmc   +1 more source