Results 41 to 50 of about 80,002 (339)

Mild hypothermia does not attenuate platelet aggregation and may even increase ADP-stimulated platelet aggregation after clopidogrel treatment

open access: yesThrombosis Journal, 2009
Background Mild hypothermia is currently standard of care for cardiac arrest patients in many hospitals and a common belief is that hypothermia attenuates platelet aggregation.
Erlinge David   +2 more
doaj   +1 more source

Hypothermia-Induced Ubiquitination of Voltage-Dependent Anion Channel 3 Protects BV2 Microglia Cells From Cytotoxicity Following Oxygen-Glucose Deprivation/Recovery

open access: yesFrontiers in Molecular Neuroscience, 2020
Background: Hypothermia attenuates microglial activation and exerts a potential neuroprotective effect against cerebral ischemic-reperfusion (I/R) injury. However, the underlying mechanism remains to be elucidated.
Shen Zhao   +12 more
doaj   +1 more source

Induced and Accidental Hypothermia

open access: yesCritical Care and Resuscitation, 2000
To review human thermoregulation and the pathophysiology and management of induced and accidental hypothermia.A review of studies reported over ten years from 1990 to 2000 and identified through a MEDLINE search of the English-language literature on thermoregulation and induced and accidental hypothermia.Hypothermia is defined as a core temperature ...
E, Connolly, L I, Worthley
openaire   +2 more sources

Comparison between Gel Pad Cooling Device and Water Blanket during Target Temperature Management in Cardiac Arrest Patients [PDF]

open access: yesAcute and Critical Care, 2018
Background: Target temperature management (TTM) improves neurological outcomes for comatose survivors of out-of-hospital cardiac arrest. We compared the efficacy and safety of a gel pad cooling device (GP) and a water blanket (WB) during TTM. Methods: We
Yoon Sun Jung   +3 more
doaj   +1 more source

Therapeutic hypothermia reduces inflammation and oxidative stress in the liver after asphyxial cardiac arrest in rats [PDF]

open access: yesAcute and Critical Care, 2020
Background Few studies have evaluated the effects of hypothermia on cardiac arrest (CA)-induced liver damage. This study aimed to investigate the effects of hypothermic therapy on the liver in a rat model of asphyxial cardiac arrest (ACA).
Yoonsoo Park   +8 more
doaj   +1 more source

Induced Hypothermia for Acute Stroke [PDF]

open access: yesStroke, 2007
Induced hypothermia is one of the most promising neuroprotective therapies. Technological limitations and homeostatic mechanisms that maintain core body temperature have impeded the clinical use of hypothermia. Recent advances in intravascular cooling catheters and successful trials of hypothermia for cardiac arrest and neonatal asphyxia renewed ...
Thomas M, Hemmen, Patrick D, Lyden
openaire   +2 more sources

Hyperbilirubinemia exaggerates endotoxin-induced hypothermia [PDF]

open access: yesCell Cycle, 2015
Systemic inflammation is accompanied by an increased production of reactive oxygen species (ROS) and by either fever or hypothermia (or both). To study aseptic systemic inflammation, it is often induced in rats by the intravenous administration of bacterial lipopolysaccharide (LPS).
Pakai, Eszter   +4 more
openaire   +3 more sources

The RNA-binding protein RBM3 is involved in hypothermia induced neuroprotection

open access: yesNeurobiology of Disease, 2011
Induced hypothermia is the only therapy with proven efficacy to reduce brain damage after perinatal asphyxia. While hypothermia down-regulates global protein synthesis and cell metabolism, low temperature induces a small subset of proteins that includes ...
Sophorn Chip   +6 more
doaj   +1 more source

Enhanced sensitivity of postsynaptic serotonin-1A receptors in rats and mice with high trait aggression [PDF]

open access: yes, 2001
Individual differences in aggressive behaviour have been linked to variability in central serotonergic activity, both in humans and animals. A previous experiment in mice, selectively bred for high or low levels of aggression, showed an up-regulation of ...
Boer, Sietse F. de,   +5 more
core   +1 more source

Role of TRPM8 in switching between fever and hypothermia in adult mice during endotoxin-induced inflammation

open access: yesBrain, Behavior, & Immunity - Health, 2021
Transient receptor potential melastatin 8 (TRPM8) functions in the sensing of noxious and innocuous colds; however, its significance in pathogen-induced thermoregulation remains unclear.
Chinatsu Shiraki   +6 more
doaj   +1 more source

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