Results 81 to 90 of about 76,226 (325)

Preclinical discovery of duloxetine for the treatment of depression [PDF]

open access: yes, 2012
Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María   +4 more
core   +2 more sources

Anatolian ground squirrel (Spermophilus xanthoprymnus) retina: Comparative expression of synaptophysin, NeuN, calbindin‐D28k, parvalbumin, glial fibrillary acidic protein, and Iba‐1 during pre‐hibernation and hibernation

open access: yesThe Anatomical Record, EarlyView.
Abstract Hibernation induces significant molecular and cellular adaptations in the retina to maintain function under reduced metabolic conditions. This study aimed to investigate the expression of neuronal, synaptic, and glial markers in the retina of Spermophilus xanthoprymnus during pre‐hibernation and hibernation periods using immunohistochemical ...
Mehmet Özbek   +5 more
wiley   +1 more source

Adding ROS Scavengers to Cold K\u3csup\u3e+\u3c/sup\u3e Cardioplegia Reduces Superoxide Emission During 2 h Global Cold Cardiac Ischemia [PDF]

open access: yes, 2012
We reported that the combination of reactive oxygen species (ROS) quenchers Mn(III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), catalase, and glutathione (MCG) given before 2 hours cold ischemia better protected cardiac mitochondria against cold ...
Aldakkak, Mohammed   +4 more
core   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

open access: yesBMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah   +9 more
wiley   +1 more source

Oklahoma Heart Hospital: Clinician Leaders Establish Culture of Quality [PDF]

open access: yes, 2009
Describes strategies for a culture of quality, including a flat organizational structure, optimal nurse experience and ratios, standardization through care sets, technology-enabled feedback and assessment, and continuous improvement through new ...
Sharon Silow-Carroll
core  

Neuroprotective Properties of Xenon. [PDF]

open access: yes, 2020
Xenon is a rare noble gas that was introduced into clinical practice more than 70 years ago. Xenon's clinical properties are predicated by its ability to fit into preformed cavities of macromolecules thereby altering their biological functions.
Laitio, Timo, Maze, Mervyn
core  

Severe Vasoplegic Syndrome Treated with Angiotensin II and Hemoadsorption Therapy after Cardiac Surgery

open access: yesCatheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Vasoplegic syndrome (VS) is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). The main pathophysiology mechanism of VS includes a systemic inflammatory response syndrome due to surgical trauma, release of pro‐inflammatory mediators caused by blood contact with foreign surfaces of heart‐lung machine (pump and tubing)
Matteo Lucchelli   +3 more
wiley   +1 more source

Characterization of N6-Cyclohexyladenosine-Induced Hypothermia in Syrian Hamsters

open access: yesJournal of Pharmacological Sciences, 2005
The N6-cyclohexyladenosine (CHA)-induced hypothermia in Syrian hamsters was characterized as follows: intracerebroventricular injection of CHA-induced hypothermia and the potency was increased by lowering the ambient temperature.
Mitsuteru Shintani   +3 more
doaj  

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