Results 91 to 100 of about 251,897 (248)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Impedance studies of 2D azimuthally symmetric devices of finite length
Physical Review Special Topics. Accelerators and Beams, 2014 In particle accelerators, the beam quality can be strongly affected by the interaction with self-induced electromagnetic fields excited by the beam in the passage through the elements of the accelerator.
N. Biancacci +5 more
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
HeliyonAiming at the multi-attribute bilateral matching problem with unknown attribute weights under a linguistic intuitionistic fuzzy environment, a decision method based on TODIM considering satisfaction and fairness degrees is proposed.
Shijie Huang, Qi Yue, Yuan Tao
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Two short proofs of the Perfect Forest Theorem
Theory and Applications of Graphs, 2017 A perfect forest is a spanning forest of a connected graph $G$, all of whose components are induced subgraphs of $G$ and such that all vertices have odd degree in the forest.
Yair Caro, Josef Lauri, Christina Zarb
doaj +1 more source
On Graphs with Induced Matching Number Almost Equal to Matching Number
Electronic Notes in Discrete Mathematics, 2015 Abstract Kobler and Rotics in 2003, and Cameron and Walker in 2005, gave a complete structural description of the graphs G where the matching number ν ( G ) equals the induced matching number ν 2 ( G ) . We study their result and use it to analyse graphs G with ν ( G ) − ν 2 ( G ) ≤ k .
Marcio Antônio Duarte +4 more
openaire +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source