Results 51 to 60 of about 411,297 (242)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Hemi-Masquelet technique and nailing in a circumferential bone defect of 7 cm after open femoral shaft fracture. A case report

Trauma Case Reports
The treatment of Gustilo-Anderson type III open femoral fracture with large segmental bone defect remains a challenge for orthopedic trauma surgeons. The aims of management are first to prevent the risk of infection and then to reconstruct the bone loss ...
Joffrey Boucly, André-Pierre Uzel
doaj   +1 more source

Surgical technique and indications of the induced membrane procedure in children

Orthopaedics & Traumatology: Surgery & Research, 2016
The induced membrane technique is now quite adaptable to segmental bone reconstruction in children. This technique is much the same as the technique used in adults. A cement spacer is interposed, and in a second operating phase, occurring 6 weeks after the interposition of the spacer, the cement is removed and a morselized corticocancellous graft is ...
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Outcome of multi-staged induced membrane technique based on post-debridement cultures for the management of critical-sized bone defect following fracture-related infection

Scientific Reports, 2022
The authors’ institution utilizes multi-staged induced membrane technique protocol based on post-debridement culture in treating patients with critical-sized bone defect in lower extremity due to infected nonunion or post-traumatic osteomyelitis.
Jae-Woo Cho, William T. Kent, Jin-Kak Kim, Seong-Ho Jeong, Seungyeob Sakong, Hanju Kim, Whee Sung Son, Eic Ju Lim, Wonseok Choi, Jong-Keon Oh   +9 more
doaj   +1 more source

Induced membrane technique using an equal portion of autologous cancellous bone and β-tricalcium phosphate provided a successful outcome for osteomyelitis in large part of the femoral diaphysis - Case report

Trauma Case Reports, 2021
Background: No report has yet described good prognosis following the induced membrane technique (IMT) for bone defects over 200 mm. Case presentation: A 46-year-old male developed osteomyelitis over a large portion of the right femoral diaphysis, which ...
Gen Sasaki, Yoshinobu Watanabe, Youichi Yasui, Kentaro Matsui, Hirotaka Kawano, Wataru Miyamoto   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Reconstruction of Large Bone Defects Using induced membrane Technique of Masquelet [PDF]

Zagazig University Medical Journal
Background: Management of large bone defects is a challenge for the surgeon and the patient as well, many functional and psychological disabilities results on and must be properly dealt with.Masquelet technique saves time, easily performed and can give ...
Mohammed soliman, Yousif Khira, .mohamed Elzoheiry, ahmad abdelwahab   +3 more
doaj   +1 more source

Repair of tibial bone defects with fibular fragment and the induced membrane technique [PDF]

Гений oртопедии, 2019
Introduction High-energy tibial fractures are challenging injuries to treat. Objective We report a case of a tibial gunshot fracture treated at several stages. Material and methods The fracture was first stabilized with external fixation device.
Alexander I. Mitrofanov, Al Delamy O.K., Al Harris M.S.   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source