Results 211 to 220 of about 10,022,913 (342)

The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.

Molecules and Cells, 2018
Liang Chen, Jia-Yu Chen, Yi-Jou Huang, Y. Gu, J. Qiu, Hao Qian, C. Shao, Xuan Zhang, Jing Hu, Hai-Ri Li, Shunmin He, Yu Zhou, O. Abdel-Wahab, Dong-er Zhang, Xiang-Dong Fu   +14 more
semanticscholar   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

The mosaicism of Cas-induced mutations and pleiotropic effects of scarlet gene in an emerging model system. [PDF]

Heredity (Edinb)
Xu S, Neupane S, Wang H, Pham TP, Snyman M, Huynh TV, Wang L.   +6 more
europepmc   +1 more source

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

Proceedings of the National Academy of Sciences of the United States of America, 1991
D. Brash, J. Rudolph, J. Simon, A. Lin, Gregory J. McKenna, H. Baden, A. Halperin, J. Pontén   +7 more
semanticscholar   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Gamma Ray-induced Mutations in pyrEF Genes in Frankia casuarinae Strain CcI3. [PDF]

Microbes Environ
Kucho KI, Han O, Yunoki M.
europepmc   +1 more source

Surrogate reporter-based enrichment of cells containing RNA-guided Cas9 nuclease-induced mutations

Nature Communications, 2014
S. Ramakrishna, S. Cho, Sojung Kim, Myungjae Song, Ramu Gopalappa, Jin-Soo Kim, H. Kim   +6 more
semanticscholar   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A new Drosophila melanogaster research resource: CRISPR-induced mutations for clonal analysis of fourth chromosome genes. [PDF]

G3 (Bethesda)
Weasner BM, Weasner BP, Cook KR, Stinchfield MJ, Kondo S, Saito K, Kumar JP, Newfeld SJ.   +7 more
europepmc   +1 more source