Results 241 to 250 of about 10,022,913 (342)

CRISPRpic: fast and precise analysis for CRISPR-induced mutations via prefixed index counting. [PDF]

NAR Genom Bioinform, 2020
Lee H, Chang HY, Cho SW, Ji HP.
europepmc   +1 more source

Induced Host-Range Mutations in Bacteriophage [PDF]

Proceedings of the National Academy of Sciences, 1953
B, Fernandez, F L, Haas, O, Wyss
openaire   +2 more sources

Genomic landscape of high-grade meningiomas [PDF]

, 2017
Artyomov, Maksym, Dunn, Gavin P, Esaulova, Ekaterina, et al,   +3 more
core   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Characteristics of induced mutations in offspring derived from irradiated mouse spermatogonia and mature oocytes. [PDF]

Sci Rep, 2020
Satoh Y, Asakawa JI, Nishimura M, Kuo T, Shinkai N, Cullings HM, Minakuchi Y, Sese J, Toyoda A, Shimada Y, Nakamura N, Uchimura A.   +11 more
europepmc   +1 more source

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

Nature Medicine, 2018
Nikolaos Zacharakis, Harshini Chinnasamy, Mary A. Black, Hui Xu, Yong-Chen Lu, Zhili Zheng, A. Pasetto, Michelle M. Langhan, Thomas E. Shelton, Todd D Prickett, J. Gartner, Li Jia, Kasia Trebska-Mcgowan, R. Somerville, P. Robbins, S. Rosenberg, Stephanie L. Goff, S. Feldman   +17 more
semanticscholar   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Elevating seed oil content in a polyploid crop by induced mutations in SEED FATTY ACID REDUCER genes. [PDF]

Plant Biotechnol J, 2020
Karunarathna NL, Wang H, Harloff HJ, Jiang L, Jung C.   +4 more
europepmc   +1 more source

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

Science, 2004
E. Valente, P. Abou-Sleiman, V. Caputo, M. Muqit, K. Harvey, S. Gispert, Zeeshan Ali, D. Del Turco, A. Bentivoglio, D. Healy, A. Albanese, R. Nussbaum, R. González-Maldonado, T. Deller, S. Salvi, P. Cortelli, W. Gilks, D. Latchman, R. Harvey, B. Dallapiccola, G. Auburger, N. Wood   +21 more
semanticscholar   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source