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Specificity of spontaneous mutations induced in mutA mutator cells
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2004Escherichia coli cells expressing the mutA allele of a glyV (glycine tRNA) gene express a strong mutator phenotype. The mutA allele differs from the wild type glyV gene by a base substitution in the anticodon such that the resulting tRNA misreads certain aspartate codons as glycine, resulting in random, low-level Asp-->Gly substitutions in proteins ...
Sergey, Balashov, M Zafri, Humayun
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Nature, 1967
VIRUS particles have been shown to induce chromosome breakage in mammalian tissue culture1–4. If it were a property of viruses to break chromosomes, then one would expect viruses to cause point mutation which would result from errors in the genetic code at the site where the chromosome was broken and reconstituted. With this reasoning, experiments were
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VIRUS particles have been shown to induce chromosome breakage in mammalian tissue culture1–4. If it were a property of viruses to break chromosomes, then one would expect viruses to cause point mutation which would result from errors in the genetic code at the site where the chromosome was broken and reconstituted. With this reasoning, experiments were
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Analysis ofMutator-induced mutations in theIojap gene of maize
Molecular and General Genetics MGG, 1996The recessive nuclear mutation iojap (ij) in maize produces striped plants with normal chloroplasts in green sectors and poorly developed chloroplasts in the white sectors. The ij mutation is also characterized by an array of additional phenotypic affects which suggests a pivotal role for Ij in chloroplast development.
M, Byrne, W C, Taylor
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Israel Journal of Plant Sciences, 2007
Maize is one of the most powerful genetic systems for studying plant biology, and an important model system for the grasses. Key to its utility is the wide range of mutations that have been and can be induced in its genome. Here we review the current uses of mutagens in maize, including the wide range of endogenous transposable elements, as well as ...
Rita-Ann Monde, Clifford F. Weil
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Maize is one of the most powerful genetic systems for studying plant biology, and an important model system for the grasses. Key to its utility is the wide range of mutations that have been and can be induced in its genome. Here we review the current uses of mutagens in maize, including the wide range of endogenous transposable elements, as well as ...
Rita-Ann Monde, Clifford F. Weil
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Dependence of induced mutation on spontaneous mutation in Tribolium castaneum
Nature, 1976IN plants the effect of physical and chemical mutagens has been found to depend on the frequency of spontaneous mutation1,2, but no such information is available from animal material. I have therefore investigated the relationship between spontaneous and X-ray-induced somatic mutation in the flour beetle Tribolium castaneum. This relationship was found
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Genetic Aspects of Induced Mutation
1978Genetic variability within the human species as well as within animal species used for mutagenicity testing may lead to misclassification of potentially mutagenic agents. Such genetic variability should be considered on three levels: uptake of the agent, its metabolism, and its action on the DNA.
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Nature, 1962
Radiation, Genes and Man By Prof. Bruce Wallace and Prof. Th. Dobzhansky. Pp. xii + 205. (London: Methuen and Co., Ltd., 1960.) 18s. net.
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Radiation, Genes and Man By Prof. Bruce Wallace and Prof. Th. Dobzhansky. Pp. xii + 205. (London: Methuen and Co., Ltd., 1960.) 18s. net.
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1999
Mutations constitute an important risk to human health. If induced in the germline they may be transmitted to the progeny causing hereditary diseases. Somatic mutations contribute to the induction of cancer. The basic mechanisms can be studied at the cellular level in tissue culture systems. On the other hand can mutations also be investigated in human
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Mutations constitute an important risk to human health. If induced in the germline they may be transmitted to the progeny causing hereditary diseases. Somatic mutations contribute to the induction of cancer. The basic mechanisms can be studied at the cellular level in tissue culture systems. On the other hand can mutations also be investigated in human
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