Results 281 to 290 of about 10,022,913 (342)
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Mutations and mechanisms of WNT pathway tumour suppressors in cancer
Nature Reviews Cancer, 2020J. Bugter, Nicola Fenderico, M. Maurice
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Molecular and General Genetics MGG, 1988
Two complementary 24 base single stranded oligonucleotides containing randomly located inosine residues were synthesized in vitro. Once annealed, the two oligonucleotides were cloned into derivatives of ColE1 and transformed into Escherichia coli. Sequence analysis of 157 clones yielded 305 mutations. The pattern of the mutations revealed the following:
P L, Nordmann +2 more
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Two complementary 24 base single stranded oligonucleotides containing randomly located inosine residues were synthesized in vitro. Once annealed, the two oligonucleotides were cloned into derivatives of ColE1 and transformed into Escherichia coli. Sequence analysis of 157 clones yielded 305 mutations. The pattern of the mutations revealed the following:
P L, Nordmann +2 more
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Current Opinion in Genetics & Development, 1992
Some spontaneous mutations are specifically 'adaptive' in two ways: in that they occur more often when they are useful than when they are irrelevant to the survival of the cell; and in that they occur as specific responses to selective pressures. These 'selection-induced mutations' occur both in bacteria and in the eukaryotic microorganism, yeast.
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Some spontaneous mutations are specifically 'adaptive' in two ways: in that they occur more often when they are useful than when they are irrelevant to the survival of the cell; and in that they occur as specific responses to selective pressures. These 'selection-induced mutations' occur both in bacteria and in the eukaryotic microorganism, yeast.
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Targeted screening for induced mutations
Nature Biotechnology, 2000With the accumulation of large-scale sequence data, emphasis in genomics has shifted from determining gene structure to testing gene function, and this relies on reverse genetic methodology. Here we explore the feasibility of screening for chemically induced mutations in target sequences in Arabidopsis thaliana.
C M, McCallum +3 more
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Nature, 1967
VIRUS particles have been shown to induce chromosome breakage in mammalian tissue culture1–4. If it were a property of viruses to break chromosomes, then one would expect viruses to cause point mutation which would result from errors in the genetic code at the site where the chromosome was broken and reconstituted. With this reasoning, experiments were
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VIRUS particles have been shown to induce chromosome breakage in mammalian tissue culture1–4. If it were a property of viruses to break chromosomes, then one would expect viruses to cause point mutation which would result from errors in the genetic code at the site where the chromosome was broken and reconstituted. With this reasoning, experiments were
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Induced mutations and barley improvement
Theoretical and Applied Genetics, 1971Seven barley varieties, originating from three X-ray induced mutations, have been officially approved in Sweden since 1958. Some have gained a wide area of cultivation. The list is as follows: Pallas, isolated 1947, approved 1958, mutant ert-k (32) of Bonus barley. - Mari, isolated 1950, approved 1960, mutant mat-a (8) of Bonus. - Hellas, approved 1967,
A, Gustafsson +3 more
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Ultraviolet-induced mutation in Streptomyces induces
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1969Abstract The wild-type strain Streptomyces indicus Chakrabarty and 4 mutant strains derived from it were irradiated by UV rays of 253.7 nm wavelength at 100 erg/mm 2 /sec, for 20, 40, 60 and 80 sec. The survival curve was exponential, and the rate of mutation was parallel with the increasing dosage and was followed later by a decline.
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Characterization of nickel-induced mutations
Science of The Total Environment, 1994A Chinese hamster ovary cell line (designated AS52) has been used to test the mutagenicity of nickel compounds. This line lacks the endogenous gene for hypoxanthine phosphoribosyl transferase (HPRT) but contains an inserted bacterial gene coding for the enzyme guanine-hypoxanthine phosphoribosyl transferase (gpt) which is the targeted locus for ...
F E, Rossetto, J D, Turnbull, E, Nieboer
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Mutations induced by ultraviolet light
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005The different ultraviolet (UV) wavelength components, UVA (320-400 nm), UVB (280-320 nm), and UVC (200-280 nm), have distinct mutagenic properties. A hallmark of UVC and UVB mutagenesis is the high frequency of transition mutations at dipyrimidine sequences containing cytosine.
Gerd P, Pfeifer +2 more
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Nitrosoguanidine-induced mutations inStreptomyces indicus
Folia Microbiologica, 1979The mutagenic activities of five 1-alkyl derivatives of 3-nitro-1-nitrosoguanidine, viz. methyl, ethyl, propyl, isopentyl and octyl, were tested on Streptomyces indicus. All the compounds were found to be mutagenic. The methyl and ethyl derivatives were most effective regarding mutational frequency. The effectiveness decreased with increasing number of
S, Sarkar, S L, Chakrabarty
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