Results 81 to 90 of about 6,425,638 (291)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Analysis and Optimization of Tooth Surface Contact Parameter of ZC1 Worm Gear

open access: yesJixie chuandong, 2016
Based on the meshing theory of ZC1 worm gear pair,the tooth surface contact parameters are analyzed by using MATLAB.The results show that the axial module,center distance,lead angle,radius of arc tooth profile of grinding wheel have great influence on ...
Song Lijuan, Ji Weixi, Xie Jian, Wang Yu
doaj  

ASSESSMENT OF THERMAL AND FORCE EFFECTS ON AN ORTHOTROPIC SHELL WITH POSITIVE GAUSSIAN CURVATURE

open access: yesInternational Journal for Computational Civil and Structural Engineering
A mathematical model of thermomechanical deformation is presented for a shell with positive Gaussian curvature, made of an orthotropic composite that develops induced anisotropy during loading.
Alexander Treschev   +2 more
doaj   +1 more source

Retinoic acid metabolic change in retina and choroid of the guinea pig with lens-induced myopia

open access: yesInternational Journal of Ophthalmology, 2012
AIM: To investigate the role of retinoic acid (RA) and retinaldehyde dehydrogenase-2 (RALDH2) of retina and choroid in the guinea pig lens-induced myopic eyes.METHODS: Totally 45 guinea pigs, at age of three weeks, were randomly assigned into three ...
Jun-Feng Mao   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Curvature-Induced σ-Enhancement at the Fermi Level in Carbon Schwarzites: A Local-Normal Analysis

open access: yes
Local-normal PDOS decomposition reveals a systematic 4% σ-enhancement beyond the isotropic baseline in D-type carbon schwarzite C136, correcting a previous coordinate-artifact interpretation. First quantitative measurement of how negative Gaussian curvature modifies π/σ orbital balance in carbon.
openaire   +4 more sources

MESHING PERFORMANCE ANALYSIS OF TAPERED ROLLER ENVELOPING END FACE MESHING WORM DRIVE (MT)

open access: yesJixie qiangdu, 2023
The end face meshing worm drive with tapered roller envelope has many simultaneous meshing tooth pairs and can eliminate clearance. According to the gear meshing principle and differential geometry principle, the meshing mathematical model of the ...
WEN YuJie   +3 more
doaj  

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Hyperglycemia Alters the Structure and Hemodynamics of the Developing Embryonic Heart

open access: yesJournal of Cardiovascular Development and Disease, 2018
Congenital heart defects (CHDs) represent the most common form of human birth defects; approximately one-third of heart defects involve malformations of the outflow tract (OFT). Maternal diabetes increases the risk of CHD by 3–5 fold.
Taylor B. Lawson   +5 more
doaj   +1 more source

Curvature‐driven Multi‐stream Network for Feature‐preserving Mesh Denoising

open access: yes
Mesh denoising is a fundamental yet challenging task. Most of the existing data‐driven methods only consider the zero‐order information (vertex location) and first‐order information (face normal).
Zhao, Zhibo   +2 more
core   +1 more source

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