Results 61 to 70 of about 6,425,638 (291)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Application of the Solving Methods and Numerical Differentiation for Curvature Parameter of Conjugate Surface

Jixie chuandong, 2017
It is a basic problem to solve the principal curvature and direction of conjugate surface. Aiming at the complex and complicated problem of the conventional method to solve the principal direction and the principal curvature of conjugate tooth surface,a ...
Zhou Weiguang, Wei Bingyang, Ouyang Hongfei, Wei Yihao   +3 more
doaj  

A curvature-corrected immersion boundary method for adaptive Cartesian meshes

Kongqi donglixue xuebao
In Cartesian grid methods, the non-body-fitted nature between orthogonal grids and complex solid boundaries poses a significant challenge for accurately imposing boundary conditions, which directly impacts simulation accuracy.
Shangzhi Sun, Canyan Luo, Bofu Wang, He Gao, Lin Bi   +4 more
doaj   +1 more source

Effects of Chamber Width on H2/Air Rotating Detonations

International Journal of Aerospace Engineering, 2020
To get the effects of chamber width on the H2/Air rotating detonations, several models with different widths have been investigated. By using a one-step chemical reaction model, one wave is induced in all models.
Hailong Zhang, Weidong Liu, Lin Zhang, Shijie Liu, Luxin Jiang   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Geometric Characteristics of Tooth Profile and Meshing Properties Changing Laws of Composite Cycloid Planetary Drive with Small Tooth Difference

工程科学与技术, 2017
:Aimed at the problems of bigger engaging angle of cycloid-pin gear,lower reliability of turning arm bearing and higher uniform position precision of pinwheel,the composite cycloid,that has a relatively strong controllability in geometry,was utilized to ...
Han Zhenhua, Shi Wankai, Xu Lang, Liu Chang   +3 more
doaj  

Design and Experimental Verification of a Compact Robot for Large-Curvature Surface Drilling

Actuators
Automated precision drilling is essential for aircraft skin manufacturing, yet current robotic systems face dual challenges: chatter-induced inaccuracies in hole quality and limited access to confined spaces such as air inlets.
Shaolei Ren, Xun Li, Daxi Geng, Zhefei Sun, Haiyang Xu, Jianchao Fu, Deyuan Zhang   +6 more
doaj   +1 more source

CURVATURE-INDUCED RASHBA SPIN–ORBIT INTERACTION IN STRAIN-DRIVEN NANOSTRUCTURES [PDF]

, 2013
We derive the effective dimensionally reduced Schrodinger equation with spin–orbit interaction (SOI) in low-dimensional electronic strain-driven nanostructures.
P. Gentile, M. Cuoco, C. Ortix
semanticscholar   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source