Results 81 to 90 of about 6,891,254 (245)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Development of a qPCR strategy to select bean genes involved in plant defence response and regulated by the Trichoderma velutinum - Rhizoctonia solani interaction

Frontiers in Plant Science, 2016
Bean production is affected by a wide diversity of fungal pathogens, among them Rhizoctonia solani is one of the most important. A strategy to control bean infectious diseases, mainly those caused by fungi, is based on the use of biocontrol agents that ...
Sara Mayo, Eleonora Cominelli, Francesca Sparvoli, Oscar González-López, Alvaro Rodríguez-González, Santiago Gutierrez, Pedro A Casquero   +6 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Using Game Theory to Understand Systemic Acquired Resistance as a Bet-Hedging Option for Increasing Fitness When Disease Is Uncertain

Plants, 2019
Systemic acquired resistance (SAR) is a mechanism through which plants may respond to initial challenge by a pathogen through activation of inducible defense responses, thereby increasing resistance to subsequent infection attempts.
Gregory J. Reynolds, Thomas R. Gordon, Neil McRoberts   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Understanding the involvement of rhizobacteria-mediated induction of systemic resistance in biocontrol of plant diseases

, 2003
Specific strains of nonpathogenic rhizobacteria can induce systemic resistance that is effective against a range of plant pathogens. To exploit induced systemic resistance, detailed knowledge of the triggering bacterial traits involved and on signal ...
L. C. van Loon, van Loon, L.C., Pieterse, C.M.J., Bakker, P.A.H.M., Loon, L.C. van, P. A. H. M. Bakker, L. X. Ran, C. M. J. Pieterse, Ran, L.X., Phytopathology, Dep Biologie, Universiteit Utrecht   +11 more
core   +1 more source

Timing of systemic resistance induced by local exogenous ABA application within clonal network of stoloniferous herb Centella asiatica subjected to low water availability

Frontiers in Plant Science
Resistance traits of plants can be activated both at the damaged site and undamaged parts. Systemic resistance induced by local exogenous abscisic acid (ABA) application alleviated negative effect of low water availability on growth performance of clonal
Su-Juan Duan, Su-Juan Duan, Gui-Jia Sun, Yi Dan, Jie Deng, Dong-Wei Yu, Qin Wei, Chang-Fan Chen, Jie Jiang, Xue-Mei Wang, Ting-Ju Ren, Yong-Mei Liao, Jin-Song Chen   +12 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Signalling in rhizobacteria-induced systemic resistance in Arabidopsis thaliana. [PDF]

, 2002
To protect themselves from disease, plants have evolved sophisticated defence mechanisms in which the signal molecules salicylic acid, jasmonic acid and ethylene often play crucial roles.
van Loon, L.C., Pieterse, C.M.J., van Pelt, J.A., van Wees, S.C.M., Ton, J., Phytopathology, Dep Biologie, Universiteit Utrecht   +7 more
core   +1 more source

GacS-Dependent Production of 2R, 3R-Butanediol by Pseudomonas chlororaphis O6 Is a Major Determinant for Eliciting Systemic Resistance Against Erwinia carotovora but not Against Pseudomonas syringae pv. tabaci in Tobacco

Molecular Plant-Microbe Interactions, 2006
Root colonization by a plant-beneficial rhizobacterium, Pseudomonas chlororaphis O6, induces disease resistance in tobacco against leaf pathogens Erwinia carotovora subsp. carotovora SCC1, causing soft-rot, and Pseudomonas syringae pv.
Song Hee Han, Seung Je Lee, Jae Hak Moon, Keun Hyung Park, Kwang Yeol Yang, Baik Ho Cho, Kil Yong Kim, Yong Whan Kim, Myung Chul Lee, Anne J. Anderson, Young Cheol Kim   +10 more
doaj   +1 more source