Results 151 to 160 of about 4,941,962 (333)
In this paper I raise concerns that I have with what I take to be a lack of warrant for Hume’s assertion that there are only two types of reasoning – demonstrative and probable. (Hume’s fork) What I leave for others to decide is whether this lack of warrant therefore successfully undercuts Hume’s argument for the Problem of Induction.
openaire +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Proceedings of the 9th conference on Theoretical aspects of rationality and knowledge, 2003 The paper explains enumerative induction, the confirmation of a law by its positive instances, in ranking theoretic terms. It gives a ranking theoretic explication of a possible law or a nomological hypothesis. And it shows, finally, that such schemes of enumerative induction uniquely correspond to mixtures of such nomological hypotheses.
openaire +3 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Hurricane Irma 2017: Relationships with Lightning, Gravity, and Earthquakes [PDF]
Journal of Systemics, Cybernetics and Informatics, 2018 Hurricane Irma, 2017, along with other storm systems (Fig. 1) howling winds and grounding lightning (Fig. 2), tracked Caribbean mantle circuits along the tectonic trenches of Puerto Rico and Cuba.
Bruce Leybourne
doaj
Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
Cell, 2007 Kazutoshi Takahashi +6 more
semanticscholar +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source