Results 241 to 250 of about 3,897,984 (301)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Clinical Outcomes in Bacillus Calmette-Guérin-Exposed Non-Muscle-Invasive Bladder Cancer.

JAMA Netw Open
Giatsoglou M, Chatzistavrou D, Sopczynski JM, Feng G, Li R.   +4 more
europepmc   +1 more source

Preoperative binaural beats reduce remimazolam dosage and enhance safety in anesthesia induction: A randomized controlled trial. [PDF]

PLoS One
Kim HC, Sohn JY, Kim MH, Kim YJ, Chang CH, Seo JH.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Predictive value of ventriculo-arterial coupling for hypotension after induction of anaesthesia: a prospective observational cohort study. [PDF]

Intensive Care Med Exp
Le HC, Tran CBH, Nguyen TTT, Phan TNV, Nguyen DN, Duong TH, Phung THN, Dong HKT, Deryck YLJM, Le MK.   +9 more
europepmc   +1 more source

Study of remimazolam besylate for general anaesthesia and population pharmacokinetics-pharmacodynamics in elderly, hepatic or renal-insufficient patients: a protocol for a multicentre randomised controlled trial in China. [PDF]

BMJ Open
Tang M, Zhu M, Chen G, Zhu T, Yin Q.
europepmc   +1 more source

Gut Microbiota and Acute Myeloid Leukemia: State of the Art, Clinical Signals, and Translational Opportunities. [PDF]

Antibiotics (Basel)
Alvaro ME, Caserta S, Martino EA, Skafi M, Bruzzese A, Amodio N, Lucia E, Olivito V, Labanca C, Mendicino F, Vigna E, Morabito F, Gentile M.   +12 more
europepmc   +1 more source

Oleic Acid and Transferrin Synergistically Induce Serum-Free Adipogenic Differentiation of Porcine Preadipocytes via the SEPTIN4/PPARγ Axis. [PDF]

Cells
Fu Z, Li Y, Wang S, Li S, Tang D, Guo X, Qi Y, Zhao P, Liu W, Guo C, Shen Y, Yang F.   +11 more
europepmc   +1 more source