Results 261 to 270 of about 3,546,540 (364)

The reactivity of single magnesium nanoparticles towards corrosion and galvanic replacement.

Nanoscale
Brabant ALY, Knight PJ, Joyce KM, Elabbadi M, Lomonosov V, Boukouvala C, Ringe E.   +6 more
europepmc   +1 more source

Non-cell-autonomous mechanisms of tumor initiation and relapse by chromosomal instability. [PDF]

Proc Natl Acad Sci U S A
Lafirenze SJA, van Gerwen B, Quirindongo AI, Costermans N, Janssen A, Etemad B, Toonen P, Louro MAD, Hoevenaar WHM, Youssef S, de Bruin A, Brosens LAA, Jelluma N, Kops GJPL.   +13 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Prevalence, patient characteristics, and outcomes of high-dose upadacitinib in inflammatory bowel disease. [PDF]

Ther Adv Gastroenterol
Azar J, Johnkennedy R, Levine LJ, AlOmar I, AlMutairdi A, Attamimi M, Proctor DD, Gaidos JKJ, Al-Bawardy B.   +8 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Induction and Prolonged Induction With Mirikizumab in Ulcerative Colitis-A Prospective, Real-World Study From the Sicilian Network for Inflammatory Bowel Disease (SN-IBD). [PDF]

United European Gastroenterol J
Costantino G, Viola A, Iuculano A, Macaluso FS, Voti RL, Cappello M, Antoci C, Ferracane C, Sciuto M, Catarella D, Parisi S, Mocciaro F, Scrivo B, Distefano ME, Vassallo R, Minissale MG, Scalisi G, Garufi S, Rao S, Muscarella S, Tortorella V, Giangreco E, Muscianisi M, Orlando A, Fries W.   +24 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Extended High-Dose Tofacitinib Induction Improves Clinical Response in Ulcerative Colitis: A Multicenter Cohort Study. [PDF]

JGH Open
Gilmore R, Pham T, Fernandes RG, Lo S, Wright EK, Rosella O, De Cruz P, Andrew B, Vasudevan A, Gazelakis K, Moore GT, Thin L, Au K, Ghaly S, Chen C, Mohsen W, Goodwin T, Sparrow MP, Ward MG, Chew M, Garg M, Shelton E, Lawrance IC, Thorat A, da Fonseca Pereira C, Begun J, An YK.   +26 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source