Results 181 to 190 of about 247,637 (262)

Spontaneous gaseous necrotizing myofasciitis in a patient with B-cell lymphoma status-post induction chemotherapy. [PDF]

J Surg Case Rep
Shields M, Remondelli MH, Wang AM, Barzanji NK, Wang J, Madha ES, Bradley MJ, Walker PF, Graybill JC.   +8 more
europepmc   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Should Induction Chemotherapy Be Considered First-Line Therapy for Sinonasal Undifferentiated Carcinoma? [PDF]

Laryngoscope
Ma DX, Su SY, Tajudeen BA, Kuan EC.
europepmc   +1 more source

Nanoplatforms for Sentinel and Tumor‐Draining Lymph Node Mapping: From Visualization to Pathway‐Informed Staging

Advanced Healthcare Materials, EarlyView.
Lymphotropic nanoplatforms integrate multimodal imaging with therapeutic guidance to map sentinel and tumor‐draining lymph nodes, revealing functional drainage, metastatic involvement, and nodal accessibility, while providing mechanistic insight to support precision surgical and therapeutic interventions.
Xu Chen, Nina Li, Meiyan Zou, Zihao Zhou, Rongwei Xu, Weiyao Feng, Xinyuan Zhao, Li Cui   +7 more
wiley   +1 more source

Concurrent chemoradiotherapy plus nimotuzumab versus chemoradiotherapy alone for locoregionally advanced nasopharyngeal carcinoma with a suboptimal response to induction chemotherapy: a randomized phase 2 trial. [PDF]

Nat Commun
Liu LT, Sun XS, Quan TT, Li XY, Guo L, Mo HY, Guo SS, Liu SL, Huang Y, Luo DH, Sun R, Jia GD, Li JB, Liu Q, Wang P, Liang YJ, Chen J, Li YF, Cheng H, Xia WX, Qiu F, Yang JH, Yang Q, Wen DX, Yan JJ, Zhao C, Chen QY, Tang LQ, Mai HQ.   +28 more
europepmc   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

Precision management of radiotherapy interruption in locoregionally advanced nasopharyngeal carcinoma: Induction chemotherapy counteracts the survival impact in high-risk patients defined by a novel model. [PDF]

Transl Oncol
Li WJ, Su F, Ling LT, Zhu BL, Deng B, Nong QQ, Yao Y, Zhou LQ, Cheng JW, Luo XW, Li Y, Guan Y, Li L, Qu S, Zhu XD, Bi M, Liang ZG.   +16 more
europepmc   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Induction chemotherapy followed by definitive chemoradiation in patients with inoperable esophageal squamous cell carcinoma: a multicenter retrospective study. [PDF]

Discov Oncol
Sahin TK, Eroglu I, Dilli I, Sutcuoglu O, Chalabiyev E, Guven DC, Aktas BY, Kaya DM, Ates O, Ozdemir N, Yalcin S, Dizdar O.   +11 more
europepmc   +1 more source

A Naphthalimide‐Based NIR‐Emissive AIE Photosensitizer for Synergistic Apoptosis/Ferroptosis‐Mediated Antitumor Therapy and Broad‐Spectrum Bacterial Inactivation With Rapid Wound Healing

Advanced Healthcare Materials, EarlyView.
An ionic naphthalimide AIE photosensitizer (PS), TPAPV‐NIM‐M, anchors to cellular and bacterial membranes, emits in the far‐red/near‐infrared (NIR) region, and efficiently generates reactive oxygen species (ROS) under white light. Its membrane‐localized photodynamic action drives apoptosis/ferroptosis‐mediated tumor suppression and broad‐spectrum ...
Sayed Mir Sayed, Zeeshan Tahir, Fahri Alkan, Yavuz Nuri Ertas   +3 more
wiley   +1 more source