Results 51 to 60 of about 4,022,723 (284)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Sliding-Mode Current Control with Exponential Reaching Law for a Three-Phase Induction Machine Fed by a Direct Matrix Converter

Energies, 2022
The direct matrix converter (DMC) is considered to be an exciting power converter topology option for electric motor drives in industrial applications (elevators, hoists and cranes) and applications where size and weight are critical (e.g., the aerospace
Paola Maidana, Christian Medina, Jorge Rodas, Edgar Maqueda, Raúl Gregor, Pat Wheeler   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Comprehensive Investigation of Efficiency Improvement in Voltage Source Inverter Using Hybrid Carrier-Based Modulation

Energies
Voltage Source Inverters (VSIs) are essential in variable-speed drive applications, where Pulse-Width Modulation (PWM) signals are typically generated using a fixed-carrier (FC) signal.
Yu Than, Fuat Kucuk
doaj   +1 more source

Induction Machine-Based EV Vector Control Model Using Mamdani Fuzzy Logic Controller

Applied Sciences, 2022
The substantial rise in the demand for electric vehicles (EVs) has emphasized an environment-friendly and intelligent design for speed control strategies. In this paper, a Mamdani fuzzy logic controller (MFLC) was proposed to vigorously control the speed
Humayun Salahuddin, Kashif Imdad, Muhammad Umar Chaudhry, Dmitry Nazarenko, Vadim Bolshev, Muhammad Yasir   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Advanced Residual Optimal Mapping Approach for Precise Detection of Stator Faults in Induction Motors

IEEE Access
Induction motors, known for their reliability and efficiency, are widely used in various industrial applications. However, their susceptibility to failure, particularly in harsh environments, poses significant operational challenges.
Abderrahim Allal, Zakaria Lammouchi, Abderrahmane Khechekhouche, Naoui Mohamed, Khalid Alqunun, Amer Alghadhban, Ismail Marouani, Tawfik Guesmi   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source