Results 241 to 250 of about 161,573 (313)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Smart Solutions: A New Direct Current Electric Machine Design to Reduce Weight and Enhance Efficiency. [PDF]

Glob Chall
Ivliev D, Bashynska I, Kosenkov V, Boiko A, Niekrasova L, Chepovskyi I.   +5 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Neuromodulation for pediatric disorders of consciousness: bridging the gap between adult evidence and developmental reality. [PDF]

Front Neurol
Zhang Y, Zhao X.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Pain-Induced changes in corticospinal excitability are associated with adaptive changes in muscle coordination. [PDF]

Neurobiol Pain
Duport A, Diotalevi G, Morel P, Le Blanc F, Léonard G, Devanne H.   +5 more
europepmc   +1 more source

Application and prospects of brain-computer interface technology for motor function reconstruction after brachial plexus injury. [PDF]

Ann Med
Song S, Li X, Pan P.
europepmc   +1 more source

Mitochondrial Dysfunction in the Inflammatory Process of Neurodegenerative Diseases. [PDF]

Biomedicines
Nesci S.
europepmc   +1 more source

Motivation meets sleep: tuning arousal via nucleus accumbens and Basal Ganglia circuits. [PDF]

NPJ Biol Timing Sleep
Sayegh FJP, Bonnavion P.
europepmc   +1 more source

Effects of fatigue on motor unit characteristics in isometric elbow contractions across age groups. [PDF]

Front Neurosci
Kuang H, Qiu F, Liu X, Chen C.
europepmc   +1 more source