Results 151 to 160 of about 303,108 (410)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Battery powered high efficiency drive systems in practical applications [PDF]

, 2015
Since about 30 years three-phase variable speed drives are the standard industrial solution when high reliability, high ingress protection of machine and especially high efficiency are required.
Weiss, H.
core  

Mathematical description of the electric drive based on the energy-saving induction motor with individual reactive power compensation

, 2013
R. G. Mugalimov, Valeriy I. Kosmatov, A. R. Mugalimova   +2 more
openalex   +2 more sources

SPEED CONTROL OF THREE-PHASE INDUCTION MOTOR DRIVE [PDF]

, 1991
Salah Ramadan, R. Mostafa, Aiman Youssef
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Research the methods of construction positional ac drive [PDF]

, 2015
В докладе рассматриваются вопросы построения позиционных электроприводов переменного тока. Обсуждаются различные варианты построения структуры системы управления и синтеза регуляторов.
Aleko, M. N., Karachev, V. S., Kotin, D. A., Алеко, М. Н., Карачев, В. С., Котин, Д. А.   +5 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

SIMULATION AND COMPARISON OF MULTI LEVEL INVERTER USING H-BRIDGE INVERTER TOPOLOGY FOR INDUCTION MOTOR DRIVE

, 2015

openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Application of Soft Squirrel-Cage Induction Motor Starting, Braking and Retarded Speed Operation for Crane Travel Mechanisms

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2010
The paper considers an improvement of crane equipment operation, particularly, its travel mechanisms  at the expense of updating currently widely applied electric drives with squirrel-cage induction motors.
B. I. Firago, D. S. Vassilyev
doaj