Results 231 to 240 of about 100,003 (264)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

E-MASS: Electromagnetic Mechanism for Active Shifting of the Centre of Gravity in Quadrotors Under Drive Fault. [PDF]

Sensors (Basel)
Kondratiuk M, Ambroziak L, Majka A, Venkatesha Prasad RR.   +3 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Calcineurin depletion coincides with phosphorylated TDP-43 deposition in a mouse model of ALS/FTLD-TDP. [PDF]

Acta Neuropathol Commun
Waldherr SM, Eck RJ, Hincks JC, Currey HN, Goldberg M, McMillan PJ, Saxton AD, Hulsey-Vincent HJ, Latimer CS, Kraemer BC, Liachko NF.   +10 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Electrostatically actuated MEMS resonators for magnetic and electric field sensing: a review. [PDF]

Microsyst Nanoeng
Koh D, Jung Y, Kim J.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Development of intelligent controller for high performance electric drives with hybrid CSA and RERNN technique. [PDF]

Sci Rep
Prabhakaran J, Thirumoorthi P, Mathankumar M, Mangaiyarkarasi SP.   +3 more
europepmc   +1 more source

Optimized FOC control strategy for dual stators permanent magnet machine. [PDF]

Sci Rep
Elnaggar MF, Flah A, El-Bayeh CZ, Alrashed MM.   +3 more
europepmc   +1 more source

Pyroptosis in cerebral ischemia‑reperfusion injury: Molecular mechanisms and therapeutic implications (Review). [PDF]

Mol Med Rep
Li Z, Ming Q, Yang T, Liu M, Fu L, Yang J, Lu Z.   +6 more
europepmc   +1 more source