Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Online SFRA for Reliability of Power Systems: Characterization of a Batch of Healthy and Damaged Induction Motors for Predictive Maintenance. [PDF]
Sensors (Basel), 2023 Bucci G +5 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Speed Estimation of Six-Phase Induction Motors, Using the Rotor Slot Harmonics. [PDF]
Sensors (Basel), 2022 Laadjal K +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Geometric Analysis of Signals for Inference of Multiple Faults in Induction Motors. [PDF]
Sensors (Basel), 2022 Contreras-Hernandez JL +6 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Analysis of Flux Density Distribution Effects on Rotor Bar Models to Improve Energy Efficiency, Environmental Sustainability, and Economic Outcomes in Induction Motors [PDF]
Iranian Journal of Electrical and Electronic EngineeringInduction motors are highly favored in industrial applications for their ease of operation, compactness, lightweight, efficiency, low maintenance, and cost-effectiveness. They are widely used in conveyors, compressors, crushers, drills, fans, escalators,
YANAWATI YAHYA +5 more
doaj
Infrared Thermography Smart Sensor for the Condition Monitoring of Gearbox and Bearings Faults in Induction Motors. [PDF]
Sensors (Basel), 2022 Alvarado-Hernandez AI +5 more
europepmc +1 more source