Results 31 to 40 of about 166,146,026 (297)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Comparison of primiparous womenʼs childbirth experience in labor induction with cervical ripening by balloon catheter or oral misoprostol – a prospective study using a validated childbirth experience questionnaire (CEQ) and visual analogue scale (VAS)

Acta Obstetricia et Gynecologica Scandinavica, 2022
Introduction Primiparity and labor induction, especially when cervical ripening is required, are risk factors for a negative childbirth experience.
Katariina Place, Heidi Kruit, Leena Rahkonen   +2 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Outpatient labor induction—Exploring future potential by assessing eligibility in a historical cohort

Acta Obstetricia et Gynecologica Scandinavica
Introduction Labor induction rates have increased over the last decades, and in many high‐income countries, more than one in four labors are induced. Outpatient management of labor induction has been suggested in low‐risk pregnancies to improve women's ...
Kjersti Engen Marsdal, Ingvil Krarup Sørbye, Stine Bernitz, Ranveig Elise T. Sve, Kristine Ask, Mirjam Lukasse   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Clinical outcomes and feasibility of implementing outpatient labor induction with misoprostol: A prospective cohort study

Acta Obstetricia et Gynecologica Scandinavica
Introduction In response to the increasing rates of induction of labor (IOL), outpatient IOL has emerged as a potential approach to enhance women's satisfaction while reducing costs and staffing requirements.
Kjersti Engen Marsdal, Ingvil Krarup Sørbye, Stine Bernitz, Nasreen Adan, Elin Baustad Grødal, Anne Flem Jacobsen, Mirjam Lukasse   +6 more
doaj   +1 more source

Maternal and perinatal outcomes in women with and without hypertensive syndromes submitted to induction of labor with misoprostol

Hypertension in Pregnancy, 2017
Objectives: To determine maternal and perinatal outcomes according to the mode of delivery in normotensive and hypertensive women bearing a live, full-term fetus, who were submitted to labor induction with misoprostol. Methods: Retrospective cohort study.
Rossana Mariana Carvalho de Paiva Marques, Alex Sandro Rolland Souza, Francisco Edson de Lucena Feitosa, Aurélio Antônio Ribeiro da Costa, Melania Maria Ramos Amorim   +4 more
doaj   +1 more source

Oxytocin and Oxytocinase in the Obese and Nonobese Parturients during Induction and Augmentation of Labor

American Journal of Perinatology Reports, 2019
Objective To investigate differences in oxytocin (OXT) biodistribution between nonobese and obese parturients during labor. Study Design Patients with body mass index (BMI) of either ≥ 18 ≤ 24.9 kg/m2 (“nonobese”) or ≥ 30 kg/m2 (“obese ...
Annemaria De Tina, Jeremy Juang, Thomas F. McElrath, Jack D. Baty, Arvind Palanisamy   +4 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source