Results 41 to 50 of about 48,889 (263)

Identification of A p300–SP1–BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome

open access: yesAdvanced Science, EarlyView.
This study reveals a pivotal epigenetic regulatory role for the histone acetyltransferase p300, demonstrating that its acetylation of histone 3 at lysine 18 and 27 (H3K18ac and H3K27ac), alongside the formation of the p300/BRD4/SP1 complex, drives AR activation and ovarian fibrosis in PCOS.
Zhengquan Zhu   +11 more
wiley   +1 more source

Effect of goserelin and leuprolide added to the semen on reproductive performance in rabbits — Short communication [PDF]

open access: yes, 2016
The aim of this study was to evaluate the ability of two synthetic GnRH analogues, goserelin and leuprolide, to induce ovulation in rabbit does using intravaginal administration.
Gogol, Piotr
core   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

open access: yesAdvanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu   +25 more
wiley   +1 more source

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

open access: yesAdvanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao   +13 more
wiley   +1 more source

Microarray-based analysis of fish egg quality after natural or controlled ovulation

open access: yesBMC Genomics, 2007
Background The preservation of fish egg quality after ovulation-control protocols is a major issue for the development of specific biotechnological processes (e.g. nuclear transfer).
Fostier Alexis   +2 more
doaj   +1 more source

HKCOG guidelines: induction of ovulation [PDF]

open access: yes, 2012
This guideline by The Hong Kong College of Obstetricians and Gynaecologists (HKCOG) covers the classification of ovulation disorders, treatment options of various ovulation disorders, and their associated risks ...
Lee, VCY, Li, RHW, Ng, EHY, Yeung, TWY
core  

Use of Urinary Pregnanediol 3-glucuronide to Confirm Ovulation [PDF]

open access: yes, 2013
Objective Urinary hormonal markers may assist in increasing the efficacy of Fertility Awareness Based Methods (FABM). This study uses urinary pregnanediol-3a-glucuronide (PDG) testing to more accurately identify the infertile phase of the menstrual cycle
Boehringer, H.   +6 more
core   +2 more sources

Real‐Time and High‐Resolution NIR‐II‐L Imaging of Netrin‐1‐Mediated Neurovascular Coupling Driven by Dose‐Dependent Electroacupuncture

open access: yesAdvanced Science, EarlyView.
Disrupted neurovascular coupling contributes to ovarian dysfunction in polycystic ovary syndrome. Using near‑infrared II long‑wavelength imaging, this study visualizes how electroacupuncture dynamically regulates ovarian blood vessels in vivo. Immediate and cumulative stimulation elicit distinct vascular responses via a Netrin‐1 dependent mechanism ...
Yicong Wang   +15 more
wiley   +1 more source

EVALUATION OF LETROZOLE THERAPEUTIC EFFECT IN INFERTILE WOMEN [PDF]

open access: yesActa Medica Iranica, 2007
Combination therapy with clomiphene citrate plus gonadotropin (clomiphene citrate plus HMG) in induction ovulation reduce the gonadotropins dose but antiestrogenic effect of c.c. can decrease pregnancy rate.
F. Akbary-Asbagh   +6 more
doaj   +1 more source

High order multiple births in the Maltese population [PDF]

open access: yes, 1992
Triplets are a relatively rare occurrence being encountered in the Maltese Islands with an overall incidence of about 0.1 per 1000 maternities. The incidence appears to be on the increase over the last twenty years rising from the 0.08 per 1000 ...
Savona-Ventura, Charles, Zammit, Anthony
core  

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