A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
Wireless Power and Data Transfer over Inductive Links for Biomedical Applications: Recent Advances, Challenges, and Limitations. [PDF]
Micromachines (Basel)Ullah N, Barakat A, Kanaya H.
europepmc +1 more source
Advanced Science, EarlyView.A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang +12 more
wiley +1 more source
Minimally Invasive Percutaneous Achilles Repair System (PARS) Repair With vs Without Bio-inductive Scaffold Augmentation for Acute Achilles Tendon Rupture: A Retrospective Comparative Cohort Study. [PDF]
Foot Ankle OrthopGenuth G, Stavrou P, Iselin LD.
europepmc +1 more source
Single‐Atom‐Enhanced Fully Inkjet‐Printed Electrochemical Sensor for Dopamine Detection
Advanced Science, EarlyView.Fully inkjet‐printed paper‐based dopamine sensors are fabricated using nitrogen‐doped graphene acid functionalized with copper single atoms. The copper sites uniquely enhance dopamine oxidation through strong molecular adsorption, as verified by electrochemical measurements and DFT calculations. The approach highlights the potential of single‐atom inks
Martin‐Alex Nalepa +11 more
wiley +1 more source
A Framework for Short-Range Wireless Power and Data Transfer in Miniaturized High-Power, High-Bandwidth Implants. [PDF]
Micromachines (Basel)Ramaut L +3 more
europepmc +1 more source
Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics
Advanced Science, EarlyView.This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li +8 more
wiley +1 more source
Structural integrity vs. clinical utility: a critical review of bio-inductive scaffolds and autologous alternatives in rotator cuff repair. [PDF]
Front Med (Lausanne)Lan P, Fang Z, Wu B, Zhang J.
europepmc +1 more source
Metal‐Half‐Salen Chemistry for One‐Pot Mineralization on Hydrophobic Polymer Membranes
Advanced Science, EarlyView.Here we report a versatile one‐pot synthetic strategy for organic–inorganic composite membranes, which leverages a metal half‐Salen system to precisely govern the competing kinetics of coordination and hydrolysis. In contrast to conventional two‐step metal‐phenol chemistries, our integrated approach substantially simplifies the fabrication process ...
Rou‐Ming Wen +8 more
wiley +1 more source
Linking perceived stress and cognitive aging: The influence of blood pressure in Black Americans. [PDF]
J Alzheimers DisByrd DR +5 more
europepmc +1 more source