Results 121 to 130 of about 144,167 (351)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

A Review of Engineering Techniques for CMOS On-Chip Inductor Design and Quality Factor Enhancement From MHz-to-GHz Frequency Domains

IEEE Access
This paper presents a comprehensive review of engineering techniques employed to enhance the quality factor (Q-factor) of silicon-based on-chip inductors across MHz-to-GHz frequency domains. The performance of CMOS on-chip inductors is often bottlenecked
Selvakumar Mariappan, Jagadheswaran Rajendran, Norhamizah Idros, Asrulnizam Abd Manaf, Narendra Kumar, Abdullah Alghaihab, Arokia Nathan, Binboga Siddik Yarman   +7 more
doaj   +1 more source

Open-Circuit Fault Diagnosis Based on the Filter Inductor Voltage for Single- and Three-Phase Inverters [PDF]

, 2015
Xuebing Pei
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Pelaksanaan program kerjasama institusi industri di Politeknik Merlimau Melaka [PDF]

, 2013
Kerjasama institusi-industri adalah penting dalam pembangunan sistem pendidikan negara. Penglibatan industri dalam bidang pendidikan khususnya dalam sistem Pendidikan Teknik dan Vokasional (PTV) adalah amat penting bagi menjamin kebolehpasaran para
Mohd Salleh, Mohd Kamarul Afandi
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

DC-DC Boost Converter with Constant Output Voltage for Grid Connected Photovoltaic Application System [PDF]

, 2010
The main purpose of this paper is to introduce an approach to design a DC-DC boost converter with constant output voltage for grid connected photovoltaic application system.
Chan, Pui Weng
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Calibration Scheme for Large Kinetic Inductance Detector Arrays Based on Readout Frequency Response [PDF]

, 2016
Laura Bisigello, S. J. C. Yates, Vignesh Murugesan, J. J. A. Baselmans, A. Baryshev   +4 more
openalex   +1 more source