Results 71 to 80 of about 13,274 (262)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Pulse diffusion welding of female joints

Frontier Materials & Technologies
Special feature of operation of electrovacuum tubes, in particular the cathode assembly, is constant heating due to bombardment of its surface with electrons. Stable characteristics and durability of the cathode assembly depend on high-quality connection
Evgeny L. Strizhakov, Stanislav V. Nescoromniy, Yury G. Lyudmirsky, Nikolay A. Mordovtsev   +3 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Research and experimentation of an electrical fault detection system for inductors used in EV charging stations

Tạp chí Khoa học và Công nghệ
With the growing integration of electric vehicles (EVs) into daily life, the demand for reliable charging stations has significantly increased. Ensuring the electrical safety of these stations requires high-quality inductor components to maintain ...
Nguyen Dac Minh Triet, Le Hoai Nam
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

EXPERIMENTAL STUDY OF PROCESSES IN AN ATTRACTIVE-SCREEN INDUCTOR SYSTEM UNDER ADDITIONAL COIL INSERTION

Electrical engineering & Electromechanics, 2014
The article is devoted to experimental investigations of action of an additional coil inserted inside an inductor system with an attractive screen on induced current distribution in the work-piece and to determination of the coefficient of the solenoid ...
Yu.V. Batygin, E.A. Chaplygin, S.A. Shinderuk   +2 more
doaj  

Low-Loss Soft Magnetic Materials and Their Application in Power Conversion: Progress and Perspective

Energies
Amorphous and nanocrystalline alloys, as novel soft magnetic materials, can enable high efficiency in a wide range of power conversion techniques. Their wide application requires a thorough understanding of the fundamental material mechanisms, typical ...
Weiwang Wang, Jiaqi Fan, Changshen Li, Yue Yu, Anding Wang, Shengtao Li, Jinjun Liu   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

High-Frequency Model of the Toroidal Powder Core and Winding of a Litz Wire

Energies
A high-frequency model of the toroidal powder core inductor with litz wire winding is presented. In the analyzed model, the power losses that occurred in both the winding and the magnetic core were taken into account.
Marcin Pawlak, Urszula Pawlak
doaj   +1 more source

Design and investigation of 65 nm rf cmos technology lc-vco’s / Aukštadažnių, 65 nm kmop technologijos, lc įtampa valdomų generatorių projektavimas ir tyrimas

Mokslas: Lietuvos Ateitis, 2014
In this paper, two LC Voltage-Controlled Oscillators (LC-LC-VCO1 and LC-VCO2) are designed using TSMC 65 nm LP/MS/RF CMOS technology. Two arrays, one of which is a 6-bit capacitor array and the other – an array of MOS varactors, provide a wide LC-VCO ...
Vytautas Mačaitis, Vaidotas Barzdėnas
doaj   +1 more source