Results 41 to 50 of about 682 (265)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Design and Optimization Approach for the Magnetic Components of a Five-Level Current Source Rectifier

Eletrônica de Potência, 2021
This work presents a design and optimization method of the five-level current source converter magnetics components, this is a contribution of this work, since the magnetics volume information of this topology lacks in the literature.
Lisandra K. Reis, Marcelo L. Heldwein
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Magnetic properties of an ACSR conductor steel core at temperatures up to 230 ∘C and their impact on the transformer effect

IET Science, Measurement & Technology, 2021
The current density distribution between layers of steel‐reinforced conductors having an odd number of aluminum layers is modified by the transformer effect, as a result of the steel core magnetisation.
Ruyguara A. Meyberg, Farith M. Absi Salas, Luis Adriano M. C. Domingues, Márcio A. Sens, Maria Teresa Correia de Barros, Antonio C. S. Lima   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Evaluation of Filtered Spark Gap on the Lightning Protection of Distribution Transformers: Experimental and Simulation Study

Energies, 2020
Protection of transformers, as one of the most expensive equipment in the power system, against lightning overvoltage impulses is a vital task. This paper, for the first time so far, investigates the effects of a filtered spark gap on the protection ...
Mahdi Pourakbari-Kasmaei, Farhan Mahmood, Michal Krbal, Ludek Pelikan, Jaroslava Orságová, Petr Toman, Matti Lehtonen   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Review of coupled inductors in power electronics: From concept to practice

e-Prime: Advances in Electrical Engineering, Electronics and Energy
With the increasing complexity of power electronics converters, magnetic components like inductors, transformers in different configurations, etc., play important roles in shaping a power controller to meet its desired performance effectively and ...
A.K. Paul, Sai Ram B․, S.V. Kulkarni
doaj   +1 more source

First self‐resonant frequency of power inductors based on approximated corrected stray capacitances

IET Power Electronics, 2021
Inductive devices are extensively employed in power electronic systems due to their magnetic energy storage and power transfer capabilities. The current trend is towards increasing the frequency of operation in order to reduce the size of the magnetic ...
Ignacio Lope, Claudio Carretero, Jesus Acero   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source