Results 41 to 50 of about 631 (218)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Design and Optimization Approach for the Magnetic Components of a Five-Level Current Source Rectifier

Eletrônica de Potência, 2021
This work presents a design and optimization method of the five-level current source converter magnetics components, this is a contribution of this work, since the magnetics volume information of this topology lacks in the literature.
Lisandra K. Reis, Marcelo L. Heldwein
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Evaluation of Filtered Spark Gap on the Lightning Protection of Distribution Transformers: Experimental and Simulation Study

Energies, 2020
Protection of transformers, as one of the most expensive equipment in the power system, against lightning overvoltage impulses is a vital task. This paper, for the first time so far, investigates the effects of a filtered spark gap on the protection ...
Mahdi Pourakbari-Kasmaei, Farhan Mahmood, Michal Krbal, Ludek Pelikan, Jaroslava Orságová, Petr Toman, Matti Lehtonen   +6 more
doaj   +1 more source

Magnetic properties of an ACSR conductor steel core at temperatures up to 230 ∘C and their impact on the transformer effect

IET Science, Measurement & Technology, 2021
The current density distribution between layers of steel‐reinforced conductors having an odd number of aluminum layers is modified by the transformer effect, as a result of the steel core magnetisation.
Ruyguara A. Meyberg, Farith M. Absi Salas, Luis Adriano M. C. Domingues, Márcio A. Sens, Maria Teresa Correia de Barros, Antonio C. S. Lima   +5 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Review of coupled inductors in power electronics: From concept to practice

e-Prime: Advances in Electrical Engineering, Electronics and Energy
With the increasing complexity of power electronics converters, magnetic components like inductors, transformers in different configurations, etc., play important roles in shaping a power controller to meet its desired performance effectively and ...
A.K. Paul, Sai Ram B․, S.V. Kulkarni
doaj   +1 more source

First self‐resonant frequency of power inductors based on approximated corrected stray capacitances

IET Power Electronics, 2021
Inductive devices are extensively employed in power electronic systems due to their magnetic energy storage and power transfer capabilities. The current trend is towards increasing the frequency of operation in order to reduce the size of the magnetic ...
Ignacio Lope, Claudio Carretero, Jesus Acero   +2 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source