Results 51 to 60 of about 682 (265)

Next-Generation Active-Clamp Forward-Flyback Converter With Integrated Planar Transformer for 4 kW LDC

IEEE Access
This paper proposes a single-module Active-Clamp Forward-Flyback (ACFF) converter for the next-generation low-voltage DC-DC converter (LDC) ensuring 4kW output power.
Gyeong-Hyun Kwon, Dong-In Lee, Seong-Wook Jeong, Han-Shin Youn   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Analytical Models for HF-Losses of Litz Wire in Inductors With Arbitrary Winding and Gap Arrangements

IEEE Open Journal of Power Electronics
Dueto 2D fields in the core window of inductors (e.g. the fringing field caused by core gaps) large errors can occur in the winding loss calculation, when the assumptions, that the $H$-field is parallel to the winding layers and constant along the field ...
Qingchao Meng, Jurgen Biela
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Spray-coated magnetic powder composite planar inductor for compact IoT sensor node

AIP Advances, 2020
A spray coating process of magnetic powder composite material is proposed in this paper for planar inductors and transformers for small DC/DC converter.
T. Hara, M. Yamaguchi
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Fault Tolerant Dual Active Bridge Converter for Electric Vehicle Application [PDF]

Iranian Journal of Electrical and Electronic Engineering
In this paper, a dual-active bridge converter based on the utilization of two transformers is presented. The principles of operation, switching strategy, and transmission power characteristics of the proposed converter under normal operation are ...
Milad Babalou, Hossein Torkaman, Edris Pouresmaeil, Nazanin Pourmoradi   +3 more
doaj  

3D structure design of magnetic ferrite cores using gelcasting and pressure-less sintering process

AIP Advances, 2019
Gelcasting is a well established process for ceramics manufacturing which recently has been proved to be successful for soft ferrites as well. This approach is particularly interesting for power electronics application in which the magnetic components (e.
A. Stratta, B. Ahmadi, B. Mouawad, S. Robertson, L. De Lillo, L. Empringham, M. Johnson   +6 more
doaj   +1 more source