Results 21 to 30 of about 362,753 (265)

Conceptual Design of HMI and eHMI for an Autonomous Patient Transport System

Current Directions in Biomedical Engineering
This paper presents the development of a humanmachine interface (HMI) and an external human-machine interface (eHMI) for an autonomous patient transport system (APTS).
Welte Korinna, Langer Ferdinand, Schmid Peter, Holder Daniel, Maier Thomas   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Concept of a human-centered electronic health record

Current Directions in Biomedical Engineering
This paper examines the challenges and opportunities associated with the implementation of Electronic Health Records (EHR) globally and, specifically, in Germany. While EHRs promise improved accessibility and comprehensibility of patient data, healthcare
Remlinger Wolfram, Langer Ferdinand, Welte Korinna, Maier Thomas   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Advancement and evaluation of a medical organization device

Current Directions in Biomedical Engineering
In anaesthesia and intensive care medicine, managing the multitude of signal and substance lines connected to patients presents challenges, risking dislocations, incorrect treatment, and increased workload for healthcare professionals. Existing solutions
Langer Ferdinand, Welte Korinna, Widmer Jette, Schmid Peter, Maier Thomas, Trick Michael   +5 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Assessing driver distraction from in-vehicle information system: an on-road study exploring the effects of input modalities and secondary task types

Scientific Reports
In-vehicle information system (IVIS) use is prevalent among young adults. However, their interaction with IVIS needs to be better understood. Therefore, an on-road study aims to explore the effects of input modalities and secondary task types on young ...
Qi Zhong, Jinyi Zhi, Yongsheng Xu, Pengfei Gao, Shu Feng   +4 more
doaj   +1 more source

Influence of Age and Palm Surface Area on Secondary Task Performance in a Driving Simulator

Promet (Zagreb)
Gesture control allows for reduced glance interaction compared to touchscreens when controlling secondary functions in cars. However, to date, there has been a lack of research investigating the influence of age and palm surface area (PSA) on performance
Lukas FUCHS, Netmi NARASINGHE, Peter SCHMID, Thomas MAIER   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source