Results 21 to 30 of about 4,569,206 (273)

The Convergence of Nanotechnology, Biotechnology and Cancer Medicine in the Fourth Industrial Revolution

open access: yesThe Thinker, 2019
Medical technologies of the fourth industrial revolution (Industry 4.0), such as nanotechnology, biotechnology, artificial  intelligence (AI), 3D printing and advanced materials are already transforming medical technology and the pharmaceutical industry
Steven Mufamadi, Zamanzima Mazibuko
doaj   +3 more sources

Historical aspects of endocrinology development

open access: yesMìžnarodnij Endokrinologìčnij Žurnal, 2017
The historical data on the development of medicine as a science, with an emphasis on aspects of the endocrinology, are given in this paper. The role of Ukrainian and foreign scientists and their contribution to the development of the chemistry of ...
M.D. Tronko, Ya.H. Balon, O.Ya. Samson
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Reducing the Disability of Employees: Current Organizational, Medical and Socio-Economic Activities

open access: yesУправленческое консультирование, 2023
An analytical study was carried out aimed at reducing the level of disability of employees of industrial enterprises of the country. It has been revealed that the disability of employees can be a consequence of both various accidents and diseases ...
S. P. Kovalev   +3 more
doaj   +1 more source

Microbial lipases: advances in production, purification, biochemical characterization, and multifaceted applications in industry and medicine

open access: yesMicrobial Cell Factories
Lipases are biocatalysts of significant industrial and medical relevance, owing to their ability to hydrolyze lipid substrates and catalyze esterification reactions under mild conditions. This review provides a comprehensive overview of microbial lipases’
A. A. Abdelaziz   +3 more
semanticscholar   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Research topics in occupational medicine, 1990–2022: A text-mining-applied bibliometric study

open access: yesScandinavian Journal of Work, Environment & Health
OBJECTIVE: Occupational health has been influenced by societal and industrial changes. This study aimed to clarify topic trends in occupational health research in 1990–2022.
Kosuke Sakai   +8 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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