Results 31 to 40 of about 4,569,206 (273)

Medicine and the pharmaceutical industry [PDF]

Developmental Medicine & Child Neurology, 2006
One privilege of working in the health service today is the enormous range of effective therapies available to us. Advances in surgical techniques, tools, and materials have been more than matched by the vast number of pharmaceutical products addressing an ever wider range of conditions. Even for conditions where treatments have been available for many
openaire   +2 more sources

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Signals, Systems, and Environment in Industrial Food Production

Journal of Political Ecology, 1997
This paper explores characteristics of the “alternative medicine” or ecological paradigm and some of its implications for health po9licies. This paradigm suggests that many degenerative diseases (including cancer) are "caused" or accellerated by the ...
E. Paul Durrenberger, Kendall M. Thu
doaj   +1 more source

Three-Dimensional Printing and Digital Flow in Human Medicine: A Review and State-of-the-Art

Applied System Innovation, 2022
The use of exponential technologies is changing how people live and interact; this has been called the “Fourth Industrial Revolution”. Within these technologies, 3D printing is playing a leading role, especially in health.
Rodrigo Salazar-Gamarra, Hans Contreras-Pulache, Gloria Cruz-Gonzales, Salvatore Binasco, William Cruz-Gonzales, Jeel Moya-Salazar   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

La storia comparata dell’uso e delle conseguenze dell’amianto nei più importanti cantieri navali italiani dell’alto Adriatico nei “lunghi anni Settanta”

Diacronie. Studi di Storia Contemporanea, 2013
The study focuses on shipyards in north-east Italy (Trieste, Monfalcone, Venice are the interested areas) giving a tough view of the working conditions in the shipbuilding industry.
Enrico Bullian ha conseguito il titolo di Dottore di ricerca in Scienze Umanistiche, indirizzo storico e storico artistico presso l’Università degli Studi di Trieste. Ha già pubblicato monografie e saggi storici, in particolare sull’emergenza amianto. È docente in corsi sulla sicurezza sul lavoro nelle scuole secondarie ed è componente della Commissione Regionale Amianto. Svolge attività amministrativa negli enti locali della provincia di Gorizia.
doaj  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Medicine and the Pharmaceutical Industry [PDF]

European Neurology, 2002
Accessible online at: www.karger.com/journals/ene Throughout Europe, institutions providing independent research on efficacy, safety and costs of drugs and therapies are on the retreat: research at universities is increasingly impaired by administrative burdens, lack of funding and staff demoralisation.
openaire   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source