Results 31 to 40 of about 992,526 (281)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

The political economy of loose regulation: Modernity meets tradition in Hong Kong [PDF]

open access: yes, 2007
Hong Kong is a fascinating social laboratory where one can observe the interplay between powerful forces of modernization and deeply-entrenched pre-industrial consumption patterns. For decades, the former had not encroached on the autonomy of grassroots-
Mushkat, M, Mushkat, R
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

Signals, Systems, and Environment in Industrial Food Production

open access: yesJournal of Political Ecology, 1997
This paper explores characteristics of the “alternative medicine” or ecological paradigm and some of its implications for health po9licies. This paradigm suggests that many degenerative diseases (including cancer) are "caused" or accellerated by the ...
E. Paul Durrenberger, Kendall M. Thu
doaj   +1 more source

Three-Dimensional Printing and Digital Flow in Human Medicine: A Review and State-of-the-Art

open access: yesApplied System Innovation, 2022
The use of exponential technologies is changing how people live and interact; this has been called the “Fourth Industrial Revolution”. Within these technologies, 3D printing is playing a leading role, especially in health.
Rodrigo Salazar-Gamarra   +5 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Research topics in occupational medicine, 1990–2022: A text-mining-applied bibliometric study

open access: yesScandinavian Journal of Work, Environment & Health
OBJECTIVE: Occupational health has been influenced by societal and industrial changes. This study aimed to clarify topic trends in occupational health research in 1990–2022.
Kosuke Sakai   +8 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Petrography, The Tar Sands Paradise, and the Medium of Modernity [PDF]

open access: yes, 2016
This article engages with the artistic practice of petrography, the art of creating photographic images through the action of sunlight upon bitumen, the heavy-oil material that is the source of the petroleum in the Athabasca tar sands.
Cariou, Warren, Gordon, Jon
core   +1 more source

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