Results 41 to 50 of about 2,332,186 (303)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Applied SciencesThe physical capabilities of a reconfigurable assembly system (RAS) increase the agility and responsiveness of the system in highly volatile market conditions.
Daniel Guzman Vargas +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
A metallic molybdenum dioxide with high stability for surface enhanced Raman spectroscopy
Nature Communications, 2017 Semiconducting materials are potential SERS substrates as alternatives to noble metals, but often suffer from poor stabilities and sensitivities. Here, the authors use molybdenum dioxide as a SERS material, showing high enhancement factors and stability ...
Qiqi Zhang +8 more
doaj +1 more source
The improvement of standard operating procedures (SOP) and the process of grading the fresh palm fruit (BTS) at Kilang Kelapa Sawit Risda Ulu Keratong [PDF]
, 2020 Industrial Engineering and Quality Management is a branch of engineering subject that giving people knowledge about management in the industry. An industrial visit had been done due to this subject needed.
Abd Rahim, Mohd Faidhul Erfan +8 more
core +1 more source
Advanced Engineering Materials, EarlyView.The tribological behavior of 100Cr6 steel spheres textured via Vickers microindentation is evaluated under lubricated sliding by varying both dimple size and density. Fine and dense textures significantly reduce friction across all lubrication regimes, while large dimples increase it.
Farideh Davoodi +3 more
wiley +1 more source
Sustainability of food supply chains – mapping food waste and by-product synergies [PDF]
, 2015 Purpose: This conceptual paper introduces the theoretical and methodological basis of an analytical framework conceived with the purpose of bringing industrial ecology perspectives into the core of the underlying disciplines supporting studies concerned ...
Batista, Luciano +2 more
core
Numerical product design: Springback prediction, compensation and optimization [PDF]
, 2007 Numerical simulations are being deployed widely for product design. However, the accuracy of the numerical tools is not yet always sufficiently accurate and reliable.
Bonte, M.H.A. +3 more
core +3 more sources